攀枝花市首例食源感染菌血症病例中分离的乌撒拉茂沙门菌的生物学特征  

First case identification of Salmonella Uzaramo from blood caused by foodborne infection in Panzhihua in Sichuan Province

作　　者：陈嫣[1] 顾桂敏 庞载元 杨晓蓉[5] 雷高鹏[5] 封正娟 沈来红[1] 白永华[1] 许学斌[6] CHEN Yan;GU Gui-min;PANG Zai-yuan;YANG Xiao-rong;LEI Gao-peng;FENG Zheng-juan;SHEN Lai-hong;BAI Yong-hua;XU Xue-bin(Panzhihua Municipal Center for Disease Control and Prevention,Panzhihua 617000,China;Guangxi Zhuang Autonomous Region Food and Drug inspection,Nanning 530021,China;Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention,Nanning 530021,China;Panzhihua Municipal Central Hospital,Panzhihua 617000,China;Sichuan Province Center for Disease Control and Prevention,Chengdu 610000,China;Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China)

机构地区：[1]四川省攀枝花市疾病预防控制中心,攀枝花617000 [2]广西壮族自治区产品质量检验研究院,南宁530007 [3]广西壮族自治区疾病预防控制中心,南宁530021 [4]四川省攀枝花市中心医院,攀枝花617000 [5]四川省疾病预防控制中心,成都610000 [6]上海市疾病预防控制中心,上海200336

出　　处：《中国人兽共患病学报》2020年第11期913-917,共5页Chinese Journal of Zoonoses

基　　金：国家重点研发计划(No.2017YFC1600100);广西健康委课题(No.z20180988)。

摘　　要：目的研究四川省攀枝花市首次报道自临床食源性感染的菌血症患者血液检出的乌撒拉茂沙门菌的生物表型和流行病特征。方法通过菌株的生化、血清型、耐药型、基因型和分子型特征,及患者临床病史进行回顾性流行病学调查和分析。结果本次源于食源暴露的血流感染病例的病原菌鉴定为乌撒拉茂沙门菌,经同行验证和国内沙门菌血清型数据库比对确认为国内首次报道的人源感染性血清型,该菌株与数据库中1株水源乌撒拉茂的耐药、毒力和分子分型特征有明显差异,人源菌株的抗生素耐药性低而毒力强,水源株虽是多重耐药菌(MDR)但毒力弱,分子型聚类提示克隆间相似度较低。结论在我国不同地区发现的罕见沙门菌乌撒拉茂血清型受生态环境影响形成各自的毒力、耐药、分子克隆特征。We describe the first case of Salmonella Uzaramo isolated from the bloodstream infection patient caused by foodborne infection in Panzhihua in Sichuan Province.Retrospective epidemiological investigation and analysis was taken after biochemical identification,serotyping,drug resistance,genotype and molecular typing of the strain,as well as the history of the patient.Through peer-review identification and comparison with Chinese Salmonella serotype database,the strain was included as a Salmonella Uzaramo strain isolated from water,which was the first human infectious serotype reported in China.The antimicrobial resistance virulence profiles and molecular subtypes were different with the other Salmonella Uzaramo isolates from river water in database.The clinical bloodstream isolates were shown in lower-drug-resistance and higher virulence,while the isolates from the river water were multi-drug resistant(MDR)and lower virulence,which indicated that the molecular characteristics for the strains were obviously different.The rare Salmonella Uzaramo isolated from different regions and source of our country,by ecological environment to form independent virulence,drug resistance and molecular clone characteristics.

关 键 词：食源性感染 血流感染 乌撒拉茂沙门菌 多重耐药菌 

分 类 号：R378.2[医药卫生—病原生物学]