响应曲面法优化提取柴胡总皂苷的工艺  

Response surface methodology for optimizing the extraction of total saponins from Bupleurum Chinense DC

作　　者：姬海刚 杨秀芳[1,2] 惠昱昱 郭林新 JI Hai-gang;YANG Xiu-fang;HUI Yu-yu;GUO Lin-xin(College of Chemistry and Chemical Engineering,Shaanxi University of Science andTechnology,Xi’an 710021,China;Shaanxi Key Laboratory of Chemical Additives for Industry,Shaanxi University of Science and Technology,Xi’an 710021,China)

机构地区：[1]陕西科技大学化学与化工学院,陕西西安710021 [2]陕西科技大学陕西省轻化工助剂重点实验室,陕西西安710021

出　　处：《应用化工》2020年第11期2787-2790,2794,共5页Applied Chemical Industry

基　　金：陕西省科技统筹创新工程计划项目(2016KTTSNY03-04)。

摘　　要：采用乙醇加热回流提取柴胡皂苷,研究乙醇浓度、料液比、提取时间、提取温度对柴胡总皂苷得率的影响。结果表明,柴胡总皂苷的提取工艺条件是:乙醇提取浓度69%,温度61℃,时间150 min,料液比1∶20 g/mL,在此工艺参数下,柴胡皂苷的得率为3.12%。Saikosaponin was extracted by reflux heating with ethanol,the effects of ethanol concentration,material liquid ratio,extraction time and extraction temperature on the yield of Saikosaponin were studied.The result showed that the extraction conditions of Saikosaponin were as follows:the concentration of ethanol was 69%,the temperature was 61℃,the time was 150 min,the ratio of material to liquid was 1∶20 g/mL.Under these parameters,the yield of Saikosaponin was 3.12%.

关 键 词：柴胡皂苷A 柴胡总皂苷 提取 响应曲面 

分 类 号：TQ464[化学工程—制药化工] R285[医药卫生—中药学]