Tanreqing Injection(痰热清注射液) for Patients with Influenza: A Systematic Review and Meta-analysis of Randomized Controlled Trials  

作　　者：QU Chen-chen ZHAO Guo-zhen WANG Xiao-peng XU Xiao-long LI Bo GUO Yu-hong LIU Qing-quan 

机构地区：[1]Emergency Department of Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing(100010),China [2]Beijing Institute of Traditional Chinese Medicine,Beijing(100010),China [3]Capital Medical University,Beijing(100010),China [4]Beijing University of Chinese Medicine,Beijing(100010),China [5]Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases,Beijing(100010),China

出　　处：《Chinese Journal of Integrative Medicine》2020年第12期936-942,共7页中国结合医学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.81673934 and No.81774146);National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2017ZX10305501001);Beijing Municipal Administration of Hospitals of Clinical Medicine Development of Special Funding Support(No.ZYLX201611)。

摘　　要：Objective:To systematically evaluate the efficacy and safety of Tanreqing Injection(痰热清注射液,TRQI)combined with conventional treatment on clinical outcomes in the treatment of patients with influenza.Methods:The electronic databases searched were Cochrane Central Register of Controlled Trials(CENTRAL,The Cochrane Library),MEDLINE(PubMed),EMbase(OvidSP),Chinese Bio-medical Literature and Retrieval System(Sinomed),China National Knowledge Infrastructure Database(CNKI),China Science and Technology Journal Database(VIP)and WanFang Data Knowledge Service Platform,and we checked the reference sections of the retrieved articles as well.The search was performed in October 2018,and we used the randomized controlled trials(RCTs)that corresponded to the new diagnostic criteria for influenza.Two review authors independently screened the internalized articles in accordance with the Preferred Reporting Items for Systematic review and Meta-Analysis(PRISMA)statement checklist.We evaluated the quality of the articles and extracted the data from the studies using the Revmen5.3 software.Results:We included 12 RCTs of over 882 cases in this meta-analysis.Compared to conventional treatment,TRQI combined with conventional treatment could increase the total effective rate[9 RCTs,n=648,odds ratio(OR):4.92,95%confidence interval(CI):2.94,8.24,P<0.0001,random effects model],decrease the average time for fever clearance[7 RCTs,n=564,mean difference(MD):–1.08,95%CI:–1.68,–0.48,P=0.0004,random effects model]and decrease the time for resolution of cough(5 RCTs,n=362,MD:–1.76,95%CI:–2.63,–0.90,P<0.0001,random effects model).Conclusion:Based on this meta-analysis of RCTs,TRQI combined with conventional treatment had a statistically significant benefit in increasing the total effective treatment rate and reducing the time for fever clearance as well as time for resolution of cough.

关 键 词：INFLUENZA Tanreqing Injection systematic review META-ANALYSIS randomized controlled trial 

分 类 号：R259[医药卫生—中西医结合]