2019年河北省血流感染厌氧菌分布特征及耐药性分析  

Distribution and drug resistance of anaerobic bacteria in bloodstream infection in Hebei province in 2019

作　　者：温海楠[1] 张继东[2] 谢守军[1] 强翠欣 孙倩[3] 魏宏莲[3] 时东彦[3] 梁悦怡 李志荣 赵建宏 WEN Hainan;Zhang Jidong;XIE Shoujun(Department of Clinical Laboratory,Affiliated Hospital of Chengde Medical College,Hebei,Chengde 067000,China;不详)

机构地区：[1]承德医学院附属医院检验科,河北省承德市067000 [2]河北省遵化市人民医院检验科 [3]河北医科大学第二医院检验科 [4]河北省临床检验中心,石家庄市075000

出　　处：《河北医药》2020年第23期3654-3656,共3页Hebei Medical Journal

基　　金：国家科技部科技基础资源调查项目(编号:2019FY101204)。

摘　　要：目的分析河北省74所医院2019年血流感染厌氧菌的分布及耐药特征,为临床治疗厌氧菌感染提供依据。方法使用WHONET软件,回顾性分析2019年河北省29所二级医院、45所三级医院血流感染厌氧菌分离株的分布及药敏特点,按CLSI 2019年标准判断药敏结果。结果剔除重复菌株后共收集血流感染厌氧菌54株,前三位分别为脆弱拟杆菌19株、卵形拟杆菌10株、棒状双歧杆菌4株;主要集中在60~79岁年龄段,占44.4%;科室分布上,重症医学科最多,13例,占24.1%,其次为肿瘤科、普外科;万古霉素、阿莫西林/克拉维酸,甲硝唑耐药率最低,分别为0、0和0.2%;青霉素G、氨苄西林、克林霉素、头孢曲松耐药率较高,分别为42.9%、42.9%、33.3%和25.6%。结论河北省血流感染厌氧菌以拟杆菌多见,有明显的年龄及科室分布特征,对不同药物敏感性差异较大,临床需结合药敏试验结果进行厌氧菌血流感染治疗;全省实验室厌氧菌分离数量均较少,实验室需加强血流感染厌氧菌的检出能力。Objective To investigate the distribution and drug resistance features of anaerobic bacteria in bloodstream infection in 74 hospital of Hebei province in 2019,so as to provide basis for the treatment of anaerobic bacteria in clinical practice.Methods The the distribution and drug resistance features of anaerobic bacteria in bloodstream infection in 29 second grade hospitals and 45 tertiary hospitals in Hebei province in 2019 were retrospectively analyzed by means of WHONET 5.6 software.Moreover the drug susceptibility results were evaluated according to CLSI 2019 standards.Results A total of 54 strains of anaerobe strains of bloodstream infection were collected after the rejection of repeated strains.The major anaerobic bacteria were bacteroidetes fragilis(19 strains),bacteroidetes ovalis(10 strains)and bifidobacterium corbium(4 strains),which were mainly in 60~79 age group,accounting for 44.4%.In terms of department distribution,which were the most(13 cases)in department of critical care medicine,accounting for 24.1%,followed by those in department of oncology and general surgery.The drug resistance rates were the lowest in vancomycin,amoxicillin/clavulanic acid and metronidazole,which were 0,0 and 0.2%,respectively.The drug resistance rates were the highest in penicillin G,ampicillin,clindamycin and ceftriaxone,which were 42.9%,42.9%,33.3%and 25.6%,respectively.Conclusion The bacteroidetes are common in anaerobic bacteria of bloodstream infection in Hebei province,with obvious age and department distribution characteristics.There is obvious difference in sensitivity to different drugs,therefor,the clinician should use antibiotics to treat anaerobic bacteria bloodstream infection according to the antimicrobial susceptibility test results.

关 键 词：血流感染 厌氧菌 耐药性 

分 类 号：R63[医药卫生—外科学]