结核分枝杆菌与宿主相互作用的分子机制  

Molecular Basis Underlying Mycobacterium Tuberculosis-host Interaction

作　　者：谢建平[1] XIE Jianping(Institute of Modern Biopharmaceuticals,State Key Laboratory Breeding Base of EcoEnvironment and BioResource of the Three Gorges Area,School of Life Sciences,Southwest University,Chongqing 400715)

机构地区：[1]西南大学生命科学学院现代生物医药研究所三峡库区生态环境与生物资源省部共建国家重点实验室培育基地,重庆400715

出　　处：《四川师范大学学报（自然科学版）》2020年第6期711-726,F0002,共17页Journal of Sichuan Normal University（Natural Science）

基　　金：国家自然科学基金(82072246、81871182和81371851)。

摘　　要：结核分枝杆菌感染导致的结核病仍然是全球公共卫生重大威胁.深入研究结核分枝杆菌的耐药性、持留性的分子基础,以及宿主免疫应答系统组成、应答过程和重要途径,是研发新诊断、治疗和预防措施的基础.综述结核分枝杆菌操纵宿主免疫应答涉及的效应分子、细胞类型、抗原递呈过程,和未来值得研究的方向,尤其是免疫代谢和训练免疫.Tuberculosis caused by Mycobacterium tuberculosis remains a formidable public health threat.In-depth studies on the drug resistance,persistence of the pathogen,the components of host immune response,process,and pathway,are the starting point of novel diagnosis,treatment and prevention.This paper summarizes the progress regarding the effectors of Mycobacterium tuberculosis implicating in hijacking the host immune response,types of immune cells,antigen presentation,and future direction,especially the immunometabolism and trained immunity.

关 键 词：结核分枝杆菌 结核病 免疫代谢 抗原递呈 训练免疫 

分 类 号：Q93[生物学—微生物学]