制备CS-Ca^2+-SAL中空凝胶球及其对碳纳米点的缓释行为  

Preparation of CS-Ca^2+-SAL hollow hydrogel spheres and their release behaviors for carbon nanodots

作　　者：翁文婷 谢晓兰 杨建梅 孙丽丹 WENG Wenting;XIE Xiaolan;YANG Jianmei;SUN Lidan(College of Chemical Engineering and Materials Science,Quanzhou Normal University,Quanzhou 362000,Fujian,China)

机构地区：[1]泉州师范学院化工与材料学院,福建泉州362000

出　　处：《精细化工》2020年第11期2301-2307,2319,共8页Fine Chemicals

基　　金：国家自然科学基金(21502104);福建省自然科学基金(2018Y0073);泉州市高层次人才项目(2020C034R);福建省大学生创新创业项目(S201910399059)。

摘　　要：将海藻酸钠溶液(SAL)滴入壳聚糖-钙(CS-Ca^2+)分散溶液中,海藻酸钠与壳聚糖分子链之间发生物理交联的同时,也与钙离子进行同步交联,可一步制备毫米级壳聚糖-钙-海藻酸钠(CS-Ca^2+-SAL)水凝胶球。通过调控原料用量比例、滴加速度和方式,成功制备内部中空,球壁均匀,表面致密的凝胶球。以荧光性碳纳米点为标记物,考察凝胶球的溶胀性能和缓释性能。结果表明,凝胶球在中性水溶液中(pH=6.8)12 h溶胀率可达2609%,并能保持完整球形结构。溶胀性能受到pH的影响显著,处于pH=1.2的溶液体系中溶胀率最小,处于pH=6.8溶液环境中溶胀率最大。荧光凝胶球在pH=7.1的Tris-HCl缓冲液中的释放实验结果表明,对碳纳米点的释放模型符合Hixon-crowell溶蚀方程,说明凝胶球的缓释机制以溶蚀为主,扩散为辅。When sodium alginate(SAL)solution was dropped into chitosan-calcium(CS-Ca^2+)dispersion solution,the physical cross-linking between sodium alginate and the molecular chain of chitosan was also synchronous cross-linking with calcium ions.Millimeter-scale chitosan-calcium-sodium alginate(CS-Ca^2+-SAL)hydrogel spheres were prepared by one step method.The hollow hydrogel spheres with smooth surface,uniform shell and compact surface could be prepared by adjusting the proportion of raw material,drop acceleration and mode.The swelling and sustained release properties of hydrogel spheres were investigated by using fluorescent carbon nanodots as label.The results showed that the swelling rate of the hydrogel spheres was up to 2609% in neutral aqueous solution(pH=6.8)after 12 h,and the hydrogel spheres remained intact spherical structure.The swelling property of the hydrogel spheres was significantly affected by pH.The swelling rate of the hydrogel spheres was the smallest when the pH of solution was 1.2,and that was the largest at pH=6.8.The experimental results of release rate of fluorescent carbon nanodots hydrogel spheres in pH=7.1 Tris-HCl buffer solution indicated that the release mechanism of carbon nanodots was fitted well with Hixcon-crowell dissolution equation,indicating that the sustained release mechanism of hydrogel spheres was dominated by dissolution and supplemented by diffusion.

关 键 词：海藻酸钠 壳聚糖 钙离子 水凝胶球 荧光碳纳米点 医药与日化原料 

分 类 号：O648.17[理学—物理化学] TQ619.7[理学—化学]