妊娠期女性甲状腺功能筛查的对比研究及对妊娠结局的影响分析  

Significance of Thyroid Function Screening in Pregnant Women and Its Effect on Pregnancy Outcome

作　　者：周凤华[1] 陈晓燕 彭维林[1] 吴端宗[1] 高培杰[1] 赖辉添[1] 李建辉 ZHOU Fenghua;CHEN Xiaoyan;PENG Weilin;WU Duanzong;GAO Peijie;LAI Huitian;LI Jianhui(Clinical Laboratory Department,Quanzhou Women’s and Children's Hospital,Quanzhou Fujian 362100,China;Department of Maternity Care Division,Quanzhou Women’s and Children's Hospital,Quanzhou Fujian 362100,China)

机构地区：[1]泉州市儿童医院·妇幼保健院检验科,福建泉州362100 [2]泉州市儿童医院·妇幼保健院妇保科,福建泉州362100

出　　处：《中国卫生标准管理》2020年第22期75-78,共4页China Health Standard Management

摘　　要：目的探讨妊娠期女性甲状腺功能筛查的意义及对妊娠结局的影响。方法选取2018年6月—2019年5月进行甲状腺功能筛查并分娩的孕妇共866例,所有孕妇均接受甲状腺功能筛查,根据筛查结果将孕妇分为甲状腺功能异常组与健康组,采用化学发光法测定患者抗甲状腺过氧化酶自身抗体(TPO-Ab)、促甲状腺素(TSH)、游离T4(FT4)水平,对比两组孕妇TPO-Ab、TSH、FT4水平,统计并分析两组妊娠并发症及妊娠结局。结果866例孕妇中,共筛查出甲状腺功能异常85例,占9.82%(85/866),健康孕妇781例,占90.18%(781/866);甲状腺功能异常组TPO-Ab、TSH水平与健康组比较,更高,FT4水平与健康组比更低(P<0.05);甲状腺功能异常组妊娠并发症发生率为43.53%,与健康组31.07%比更高(P<0.05);甲状腺功能异常组不良妊娠结局发生率为84.71%,与健康组48.66%比更高(P<0.05)。结论妊娠期女性甲状腺功能会影响妊娠结局,妊娠早期予以甲状腺功能筛查,可及时发现甲状腺功能异常,并予以有效治疗,改善妊娠结局。Objective To explore the significance of thyroid function screening in pregnant women and its effect on pregnancy outcome.Methods A total of 866 pregnant women who were screened for thyroid function and delivered between June 2018 and May 2019,all pregnant women undergo thyroid function screening,according to the screening results,pregnant women were divided into abnormal thyroid function group and healthy group,the electrochemical luminescence method was used to determine the levels of antithyroid peroxidase autoantibody(TPO-Ab),thyroid stimulating hormone(TSH),and free thyroxine(FT4),comparing the levels of TPO-Ab,TSH and FT4 between two groups of pregnant women,statistics and analysis of pregnancy complications and pregnancy outcomes in two groups.Results Of the 866 pregnant women,85 were screened for abnormal thyroid function,accounting for 9.82%(85/866),and 781 were healthy pregnant women,accounting for 90.18%(781/866);the levels of TPO-Ab and TSH in the thyroid dysfunction group were significantly higher than those in the healthy group,and the levels of FT4 were significantly lower than those in the healthy group(P<0.05);the incidence of pregnancy complications in the thyroid dysfunction group was 43.53%,compared with the healthy group 31.07%,significantly higher(P<0.05);the incidence of adverse pregnancy outcomes in the thyroid dysfunction group was 84.71%,compared with 48.66%of the healthy group,significantly higher(P<0.05).Conclusion Hyroid function of pregnant women will affect pregnancy outcomes.Screening for thyroid function in early pregnancy can detect abnormal thyroid function in time and be treated effectively to improve pregnancy outcomes.

关 键 词：妊娠期 甲状腺功能筛查 妊娠结局 促甲状腺素 妊娠高血压 妊娠糖尿病 

分 类 号：R714[医药卫生—妇产科学]