血清25羟维生素D水平及Essen卒中风险评分量表与冠心病的相关性研究  

Relationship of serum 25-hydroxyvitamin D and Essen stroke risk score with coronary heart disease

作　　者：张晶晶[1] 祝小霞[1] 杨二丽 章雯[1] 丁旵东[1] Zhang Jingjing;Zhu Xiaoxia;Yang Erli;Zhang Wen;Ding Chandong(Department of Geriatric Cardiology,the Second Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230601,China)

机构地区：[1]安徽医科大学第二附属医院老年心血管内科,合肥230601

出　　处：《中国基层医药》2020年第23期2877-2880,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的:探讨血清25羟维生素D[25(OH)D]及Essen卒中风险评分量表(Essen Stroke Risk Scale,ESRS)与冠状动脉粥样硬化性心脏病(简称冠心病)发病的相关性。方法:纳入2016年7月至2019年1月于安徽医科大学第二附属医院老年心血管内科行冠脉造影术(coronary angiography,CAG)检查的患者186例,其中明确诊断为冠心病117例(冠心病组),非冠心病69例(非冠心病组)。收集两组患者的血清25(OH)D值及行ESRS评分,分析25(OH)D及ESRS与冠心病的关系。同时行多因素logistic回归分析血清25(OH)D及ESRS评分冠心病发病相关性。结果:冠心病组血清25(OH)D值为(38.19±16.35)nmol/L,非冠心病组血清25(OH)D为(45.37±19.01)nmol/L,两组差异有统计学意义(t=2.722,P<0.05);冠心病组ESRS评分为(2.32±1.38)分,非冠心病组ESRS评分为(1.42±1.32)分,两组差异有统计学意义(t=-4.394,P<0.05);多因素logistic回归分析显示,25(OH)D与冠心病独立相关(OR=0.944,95%CI:0.902~0.989,P=0.015),ESRS与冠心病独立相关(OR=1.716,95%CI:1.314~2.240,P<0.001)。结论:血清25(OH)D是冠心病的保护因素,ESRS亦可用于评估冠心病发病风险。Objective To investigate the correlation between serum 25-hydroxyvitamin D[25(OH)D],Essen Stroke Risk Scale(ESRS)and the incidence of coronary atherosclerotic heart disease.Methods From July 2016 to January 2019,186 patients who underwent coronary angiography(CAG)in the Department of Geriatric Cardiology at the Second Affiliated Hospital of Anhui Medical University were included.Among them,117 patients were diagnosed with coronary heart disease,69 cases without coronary heart disease.The serum 25(OH)D values and ESRS scores of the two groups were collected to analyze the relationship between 25(OH)D,and ESRS scores,coronary heart disease.At the same time,multivariate logistic regression was used to analyze the correlation between serum 25(OH)D and ESRS scores.Results The serum level of 25(OH)D in the coronary heart disease group was(38.19±16.35)nmol/L,which in the non-coronary heart disease group was(45.37±19.01)nmol/L,the difference was statistically significant difference(t=2.722,P<0.05).The ESRS scores in the coronary heart disease group was(2.32±1.38)points,which of the non-coronary heart disease group was(1.42±1.32)points,the difference was statistically significant(t=-4.394,P<0.05).Multivariate logistic regression analysis showed that 25(OH)D was independently associated with coronary heart disease(OR=0.944,95%CI:0.902-0.989,P=0.015),ESRS score was independently associated with coronary heart disease(OR=1.716,95%CI:1.314-2.240,P<0.001).Conclusion 25(OH)D is a protective factor for coronary heart disease,ESRS score is an independent risk factor for coronary heart disease.

关 键 词：冠状动脉疾病 冠状血管造影术 25-羟维生素D2 卒中风险评分量表 

分 类 号：R541.4[医药卫生—心血管疾病] R743.3[医药卫生—内科学]