阿仑膦酸钠联合鲑鱼降钙素治疗老年人髋部骨质疏松性骨折的效果观察及对患者骨代谢的影响  

Effect of alendronate combined with salmon calcitonin in the treatment of elderly patients with hip osteoporotic fracture

作　　者：李志民 黄伟军 黄鹤 张娟 张雨 Li Zhimin;Huang Weijun;Huang He;Zhang Juan;Zhang Yu(Department of Orthopaedics,Zhejiang Xin'an International Hospital,Jiaxing,Zhejiang 314000,China)

机构地区：[1]浙江新安国际医院骨科,嘉兴314000

出　　处：《中国基层医药》2020年第23期2881-2884,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的:探讨阿仑膦酸钠联合鲑鱼降钙素治疗老年人髋部骨质疏松性骨折的效果观察及对患者骨代谢的影响。方法:选择浙江新安国际医院于2016年1月至2019年12月行手术治疗的老年髋部骨质疏松性骨折患者86例,按照随机数字表法分为观察组43例与对照组43例。对照组患者给予鲑鱼降钙素治疗,观察组在对照组基础上结合阿仑膦酸钠治疗。两组患者疗程均为6个月。比较两组治疗前后血清钙和磷水平变化、髋关节Harris评分和骨代谢变化。结果:观察组治疗后血清钙和磷水平与对照组比较差异无统计学意义(均P>0.05);观察组治疗后髋关节Harris评分(87.10±3.46)分,高于对照组的(78.65±4.32)分(t=10.011,P<0.05);观察组治疗后血清I型胶原羧基末端肽交联β特殊序列(0.27±0.05)μg/L,低于对照组的(0.39±0.07)μg/L,而碱性磷酸酶(117.93±10.15)U/L,高于对照组的(98.32±8.97)U/L(t=9.147、9.493,均P<0.05)。结论:阿仑膦酸钠联合鲑鱼降钙素治疗老年髋部骨质疏松性骨折的临床效果明显,可改善患者骨代谢和髋关节功能。Objective To investigate the effect of alendronate sodium tablets combined with salmon calcitonin in the treatment of elderly patients with hip osteoporotic fracture,and the changes of serum bone metabolism.Methods From January 2016 to December 2019,86 elderly patients with osteoporotic hip fracture who were operated in Xin'an International Hospital were divided into observation group(43 cases)and control group(43 cases)according to the random digital table method.The control group was treated with salmon calcitonin,and the observation group was treated with alendronate sodium on the basis of the control group.The course of treatment was 6 months in both two groups.The changes of serum calcium and phosphorus,Harris score of hip joint and bone metabolism were compared before and after treatment.Results There were no statistically significant differences in serum calcium and phosphorus levels between the observation group and the control group(all P>0.05).After treatment,the Harris score of hip joint in the observation group[(87.10±3.46)points]was higher than that in the control group[(78.65±4.32)points](t=10.011,P<0.05).The serumβ-CTX[(0.27±0.05)μg/L]in the observation group was lower than that in the control group[(0.39±0.07)μg/L],while the ALP[(117.93±10.15)U/L]in the observation group was higher than that in the control group[(98.32±8.97)U/L],the differences were statistically significant(t=9.147,9.493,all P<0.05).Conclusion Alendronate combined with salmon calcitonin can improve the bone metabolism of elderly patients with hip osteoporotic fracture,and improve the function of hip joint.

关 键 词：骨质疏松性骨折 髋关节 髋关节功能 碱性磷酸酶 骨密度 阿仑膦酸钠 鲑鱼降钙素 老年人 

分 类 号：R683[医药卫生—骨科学] R580[医药卫生—外科学]