十二烷基苯磺酸钠与苯扎氯铵相互作用的共振光散射光谱研究及应用  

STUDY AND APPLICATION OF RESONANCE LIGHT SCATTERING SPECTRA OF INTERACTION BETWEEN SDBS AND BENZALKONIUM CHLORIDE

作　　者：李银华 彭玉次 许钟元 余梦婷 王振 马卫兴 董自波 Li Yinhua;Peng Yuci;Xu Zhongyuan;Yu Mengting;Wang Zhen;Ma Weixing;Dong Zibo(School of Environmental and Chemical Engineering,Jiangsu Ocean University,Lianyungang 222005,Jiangsu,China;School of Pharmacy,Jiangsu Ocean University,Lianyungang 222005,Jiangsu,China;School of Marine Science and Fisheries,Lianyungang 222005,Jiangsu,China;Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening,Lianyungang 222005,Jiangsu,China;Jiangsu Provincial Marine Medicinal Resources Development Engineering Research Center,Lianyungang 222005,Jiangsu,China)

机构地区：[1]江苏海洋大学环境与化学工程学院,江苏连云港222005 [2]江苏海洋大学药学院,江苏连云港222005 [3]江苏海洋大学海洋科学与水产学院,江苏连云港222005 [4]江苏省海洋药物筛选重点实验室,江苏连云港222005 [5]江苏省海洋药用资源开发工程研究中心,江苏连云港222005

出　　处：《精细石油化工》2020年第6期48-51,共4页Speciality Petrochemicals

基　　金：江苏高校品牌专业建设二期项目(省特色专业-药物制剂,编号65);江苏海洋大学研究生科研创新计划项目(KYCX19-2270、KYCX19-2269);国家自然科学基金(81773968)。

摘　　要：在pH=8.40的Clark-Lubs缓冲溶液中,基于苯扎氯铵与十二烷基苯磺酸钠(SDBS)静电结合形成离子缔合物,引起反应体系的共振光散射强度增强这一机理,建立了一种用于检测苯扎氯铵的共振光散射光谱新方法。研究表明,检测波长在285 nm处,共振光散射强度差(ΔIRLS)与浓度在0.05~1.40 mg/L的苯扎氯铵呈良好的线性关系,其线性回归方程为ΔIRLS=6918.05c-441.28,相关系数R为0.9992,检出限为0.045 mg/L。建立的方法具备操作简便、灵敏度高等特点,成功地应用于邦迪中苯扎氯铵的测定。Based on the electrostatic combination of benzalkonium chloride and sodium dodecyl benzenesulfonate(SDBS)to form an ionic association,which enhance the resonance light scattering signal of the reaction system in the Clark-Lubs buffer solution at pH=8.40.A new method of resonance light scattering spectroscopy for detecting benzalkonium chloride was established in this study.Results shown that the resonance light intensity enhancement valueΔIRLS was linear related to benzalkonium chloride with a concentration within 0.051.40 mg/L at 285 nm.The linear regression equation isΔIRLS=6918.05c-441.28.The correlation coefficient R is 0.9992,and the detection limits is 0.045 mg/L.The proposed method,which has the characteristics of simple operation and high sensitivity,was successfully applied to the determination of benzalkonium chloride in Band-Aid bandages.

关 键 词：苯扎氯铵 共振光散射光谱 十二烷基苯磺酸钠 离子缔合物 

分 类 号：TQ314.269[化学工程—高聚物工业]