除草剂呋草酮的合成  

Synthesis of Herbicide Flurtamone

作　　者：王智敏 于靓 蒋旭明 邹佩佩 WANG Zhi-min;YU Liang;JIANG Xu-ming;ZOU Pei-pei(Jiangsu Agrochem Laboratory Co.,Ltd.,Changzhou 213022,Jiangsu,China)

机构地区：[1]江苏省农用激素工程技术研究中心有限公司,江苏常州213022

出　　处：《农药》2020年第11期792-793,799,共3页Agrochemicals

摘　　要：[目的]研究除草剂呋草酮的合成方法。[方法]以间三氟甲基苯乙腈、苯乙酰氯为起始原料,经取代、环化、甲基化反应,处理后即得目标产物呋草酮。[结果]在优化反应条件下,反应总收率为80.4%(以间三氟甲基苯乙腈计),含量96%;产物结构经HPLC-MS、1H NMR确证。[结论]该反应原料易得,条件温和,操作简便,适合在工业上推广应用。[Aims]This paper aims to study the synthetic method of flurtamone.[Methods]Flurtamone can be obtained through reactions of substitution,cyclization,methylation by using 3-trifluoromethylbenzylcyanide and phenylacetyl chloride as the starting materials.[Results]The total yield was 80.4%based on 3-trifluoromethylbenzylcyanide under the optimized reaction conditions and the purity was as high as 96%.The structure of the final product was confirmed by HPLC-MS and 1H NMR.[Conclusions]The method has advantages of commercially available raw materials,mild reaction condition,simple procedure,which is suitable for popularization and application in industry.

关 键 词：除草剂 呋草酮 合成 

分 类 号：TQ460.3[化学工程—制药化工]