基于哈德曼编码的新型高分辨定域谱  

High-Resolution Localized NMR Spectroscopy Based on Hadamard-Encoding

作　　者：柯汉平 蔡宏浩 KE Han-ping;CAI Hong-hao(College of Information and Mechanical&Electrical Engineering,Ningde Normal University,Ningde 352000,China;School of Science,Jimei University,Xiamen 361021,China)

机构地区：[1]宁德师范学院信息与机电工程学院,福建宁德352000 [2]集美大学理学院,福建厦门361021

出　　处：《波谱学杂志》2020年第4期524-532,共9页Chinese Journal of Magnetic Resonance

基　　金：福建省科技厅资助项目(2016J01674);福建省中青年教师基金资助项目(JAT160542);宁德师范学院青年教师基金资助项目(2016Q58);国家自然科学基金资助项目(11705068);福建省自然科学基金资助项目(2017J05011).

摘　　要：核磁共振(NMR)技术作为一种非植入无损伤的检测技术,已经广泛应用于化学、生物和医学等领域.本文基于哈德曼(Hadamard)编码的分子间单量子相干(iSQC)技术提出了一种新的序列,首先从理论上对该序列进行了简要的分析并阐明其原理,然后用套管模型实验和脑模型实验验证该序列在不均匀磁场下准确定域和快速获取高分辨谱的能力.实验表明,该序列在不均匀磁场下可以快速获取高分辨定域谱,同时抑制溶剂峰信号,具备一定的应用价值.Nuclear magnetic resonance(NMR)is a non-invasive technology which has been widely used in chemical,biological and medical researches.This paper presents a new NMR pulse sequence based on Hadamard spatial encoding and intermolecular single-quantum coherence(iSQC)transfer.The principle of the sequence was analyzed and the theoretical considerations were presented.The performance of the sequence in accurate spatial localization and fast acquisition under inhomogeneous magnetic field were verified with phantom experiments and the brain metabolites experiments.The results demonstrated that the sequence can quickly obtain high-resolution localized spectra under inhomogeneous magnetic fields,while suppressing the solvent peaks efficiently.

关 键 词：核磁共振(NMR) 哈德曼(Hadamard)编码 分子间单量子相干(iSQC) 定域谱 不均匀磁场 

分 类 号：O482.53[理学—固体物理]