fMRI在经颅直流电刺激研究中的应用进展  

Application of fMRI in Transcranial Direct Current Stimulation Researches

作　　者：程力维 王璐璐[2] 钟凯[2] CHENG Li-wei;WANG Lu-lu;ZHONG Kai(Institutes of Physical Science and Information Technology,Anhui University,Hefei 230039,China;Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China)

机构地区：[1]安徽大学物质科学与信息技术研究院,安徽合肥230039 [2]中国科学院合肥物质科学研究院,安徽合肥230031

出　　处：《波谱学杂志》2020年第4期533-546,共14页Chinese Journal of Magnetic Resonance

基　　金：中国科学院合肥大科学中心重点研发项目(2017HSC-KPRD003);合肥物质科学技术中心培育基金(2018ZYFX005);中国科学院合肥大科学中心“高端用户培育基金”(2019HSC-UE006).

摘　　要：经颅直流电刺激(tDCS)是一种新颖的神经系统疾病治疗手段,可非侵入性调控中枢神经活动.它具有安全、成本低、疗效显著等特点,因此在神经科学等领域被大量研究和应用.功能磁共振成像(fMRI)具备高时空分辨率的优势,近年来被广泛用于tDCS治疗效果的评估及其作用机制的研究.本文从临床研究与动物模型实验两方面总结fMRI技术应用于tDCS研究中的最新进展,并讨论其应用前景.Transcranial direct current stimulation(tDCS)noninvasively modulates the excitability of the brain,and is a promising method for treating diseases in the central nervous system.tDCS is safe,effective and affordable,and has been increasingly applied in neuroscience research.Functional magnetic resonance imaging(fMRI)is a widely-used tool to evaluate the therapeutic effects and the underlying neural mechanisms of tDCS.Herein we briefly reviewed the progresses of applications of fMRI in tDCS research.Both clinical trials and animal model experiments were discussed,as well as the perspectives of future applications.

关 键 词：经颅直流电刺激(tDCS) 功能磁共振成像(fMRI) 神经系统 

分 类 号：O482.53[理学—固体物理]