布地奈德联合肺表面活性物质气管内注入防治早产儿支气管肺发育不良的效果  

Effect of Intratracheal Injection of Budesonide Combined with Pulmonary Surfactant in the Prevention and Treatment of Bronchopulmonary Dysplasia in Premature Infants

作　　者：饶军 程贤高[1] 李晓春[1] 胡方启[1] 朱良梅[1] 储振宇[1] RAO Jun;CHENG Xian-gao;LI Xiao-chun;HU Fang-qi;ZHU Liang-mei;CHU Zhen-yu(Department of Neonatology,Anqing Hospital Affiliated toAnhui Medical University,Anqing 246000,Anhui,China)

机构地区：[1]安徽医科大学附属安庆医院新生儿科,安徽安庆246000

出　　处：《医学信息》2020年第23期147-149,共3页Journal of Medical Information

摘　　要：目的探讨布地奈德联合肺表面活性物质(PS)与单独应用PS对支气管肺发育不良(BPD)的影响。方法选取2018年8月~2020年6月我院新生儿科收治的64例新生儿呼吸窘迫综合征早产儿作为研究对象,以入院时间顺序随机分成观察组和对照组,各32例。对照组给予PS气管(气管插管或LISA管)内滴入,观察组给予布地奈德联合PS气管(气管插管或LISA管)内滴入,比较两组用药前后动脉血气指标、呼吸机应用时间、吸氧时间、住院时间、BPD发生率、PS重复给药率及并发症发生率。结果给药后,两组pH值、PaO2、PaO2/FiO2高于给药前,PaCO2低于给药前,且观察组pH值、PaO2、PaO2/FiO2高于对照组,PaCO2低于对照组,差异有统计学意义(P<0.05);观察组呼吸机应用时间、吸氧时间、住院时间短于对照组,差异有统计学意义(P<0.05);观察组BPD发生率、PS重复使用率低于对照组(15.63%vs 37.50%)、(3.13%vs 21.88%),差异有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论对早产儿气管插管或LISA管下滴入布地奈德联合PS治疗,可改善患儿肺功能指标,抑制炎症反应,有效防止早产儿支气管肺发育不良发生几率,不增加其他并发症的风险,且可缩短呼吸机应用时间、总吸氧时间、住院时间,并降低PS的重复使用率。Objective To investigate the effects of budesonide combined with pulmonary surfactant(PS)and PS alone on bronchopulmonary dysplasia(BPD).Methods From August 2018 to June 2020,64 premature infants diagnosed with neonatal respiratory distress syndrome were selected from neonatology department of our Hospital.The patients were randomly divided into the observation group and the control group according to the order of admission,32 cases in each group.Observation group received budesonide combined with PS trachea(tracheal intubation or LISA tube)drip,the control group only received PS trachea(tracheal intubation or LISA tube)drip.To analyze the arterial blood gas indexes of the two groups before and after drug administration and compare the ventilator use time,oxygen intake time,hospital stay time,BPD incidence,PS repetition rate and complication rate between the two groups.Results After administration,the pH value,PaO2,PaO2/FiO2 of the two groups were higher than before administration,PaCO2 was lower than before administration,and the pH value,PaO2,PaO2/FiO2 of the observation group were higher than those of the control group,and PaCO2 was lower than the control group,the difference was statistically significant(P<0.05);the observation group's ventilator application time,oxygen inhalation time,and hospital stay were shorter than those of the control group,the difference was statistically significant(P<0.05);the observation group's incidence of BPD and PS repeated use rate was lower than the control group(15.63%vs 37.50%),(3.13%vs 21.88%),the difference was statistically significant(P<0.05);the complication rate between the two groups was not statistically significant(P>0.05).Conclusion Intratracheal intubation or LISA tube infusion of budesonide combined with PS therapy in premature infants can improve lung function indicators,inhibit inflammation,and effectively prevent the incidence of bronchopulmonary dysplasia in premature infants without increasing other complications.Risk,shorten the ventilator application time

关 键 词：早产儿 支气管肺发育不良 布地奈德 肺表面活性物质 

分 类 号：R722.6[医药卫生—儿科]