补肾活血方治疗2型糖尿病性骨质疏松的疗效观察  

Efficacy of Bushen Huoxue decoction on type 2 diabetic osteoporosis

作　　者：房其军[1] 杨海明[1] 刘莹露[1] 吴薇[1] 沈山梅[2] FANG Qi-jun;YANG Hai-ming;LIU Ying-lu;WU Wei;SHEN Shan-mei(Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing,Jiangsu 210008,China;不详)

机构地区：[1]南京大学医学院附属鼓楼医院中医科,江苏南京210008 [2]南京大学医学院附属鼓楼医院内分泌科,江苏南京210008

出　　处：《中国临床研究》2020年第11期1537-1539,共3页Chinese Journal of Clinical Research

基　　金：南京大学医院管理研究所课题研究项目(NDYG2019026)。

摘　　要：目的探讨补肾活血方治疗糖尿病性骨质疏松(DOP)的临床效果。方法选取2017年1月至2020年1月在中医科、内分泌科门诊及住院的DOP患者55例,随机分为对照组(n=27)及治疗组(n=28)。对照组在控制其他原发病基础上加用碳酸钙D3600 mg+骨化三醇胶丸0.5μg,治疗组在对照组基础上加用补肾活血方,治疗周期为6个月。观察并比较两组治疗前后VAS评分、肝功能[丙氨酸氨基转移酶(ALT)、谷氨酸氨基转移酶(AST)]、骨代谢指标[I型胶原氨基端延长肽(P1NP)、β-I型胶原羧基端肽(β-CTX)]、骨密度(腰椎L1~4及左侧股骨)。结果与对照组相比,治疗后治疗组VAS评分、β-CTX水平降低,P1NP水平升高,腰椎(L1~4)及左侧股骨骨密度增加,差异有统计学意义(P<0.05,P<0.01)。两组治疗前后肝功能指标比较差异无统计学意义(P>0.05)。结论补肾活血方可有效缓解DOP患者疼痛,改善骨代谢,增加骨密度,且无明显肝损作用。Objective To investigate the clinical effect of Bushen Huoxue decoction on diabetic osteoporosis(DOP).Methods A total of 55 outpatients or inpatients with DOP who received treatment in the Department of TCM or Endocrinology from January 2017 to January 2020 were randomly divided into control group(n=27)and treatment group(n=28).The control group was treated with calcium carbonate and vitamin D3 tablets 600 mg+calcitriol capsules 0.5μg on the basis of controlling other primary diseases,and the treatment group was added with Bushen Huoxue decoction on the basis of control group.The treatment period was 6 months.The VAS score,liver function[alanine aminotransferase(ALT),glutamate aminotransferase(AST)],bone metabolism index[type I collagen N-terminal lengthening peptide(P1NP),β-I collagen carboxyl terminal peptide(β-CTX)],bone mineral density(BMD)were observed and compared between the two groups before and after treatment.Results Compared with the control group,the VAS score andβ-CTX level in the treatment group were decreased,the P1NP level,BMD of lumbar spine(L1-4)and left femur was increased(P<0.05).There was no significant difference in liver function between the two groups before and after treatment(P>0.05).Conclusion Bushen Huoxue decoction could relieve pain,improve bone metabolism and increase bone mineral density in patients with DOP without obvious liver damage,which can be used in clinical treatment of DOP.

关 键 词：补肾活血方 糖尿病性骨质疏松 肝功能 骨密度 

分 类 号：R259[医药卫生—中西医结合] R587.1[医药卫生—中医内科学]