细胞程序性死亡在血管平滑肌增殖中的研究进展  

Research advances in programmed cell death in vascular smooth muscle proliferation

作　　者：芮博文 颜竞[1] 杨平珍[1] RUI Bowen;YAN Jing;YANG Pingzhen(Department of Cardiology,Laboratory of Heart Center,Zhujiang Hospital,Southern Medical University,Guangzhou 510515,Guangdong Province,China)

机构地区：[1]南方医科大学珠江医院心血管内科,珠江医院心脏中心实验室,广东广州510515

出　　处：《解放军医学院学报》2020年第9期930-933,942,共5页Academic Journal of Chinese PLA Medical School

基　　金：广东省基础与应用基础研究基金(2019A1515010899);广东省教育厅高水平大学建设经费南方医科大学临床研究启动项目(LC2016ZD022)。

摘　　要：目前已经发现的细胞程序性死亡包括凋亡、自噬、焦亡、铁凋亡等。以往的研究表明血管平滑肌通过增殖与细胞程序性死亡维持细胞数量的平衡,当炎症、外界损伤等刺激使平衡被打破时,会造成血管平滑肌大量增殖并引起一系列病理改变。研究细胞程序性死亡在血管平滑肌增殖中的调节机制有助于为探索血管增生性疾病的病理生理机制提供新的思路。本文将对各类细胞程序性死亡在血管平滑肌细胞增殖中作用的研究进展做一综述。Nowadays,many kinds of programmed cell death have been found,including apoptosis,autophagy,pyroptosis,ferroptosis and so on.Previous studies have revealed that vascular smooth muscle maintains the balance of cell number through proliferation and programmed cell death.When stimulated by inflammation or external injury,the balance is broken,resulting in massive proliferation of vascular smooth muscle and causing a series of pathological changes.The study of the regulation mechanism of programmed cell death in vascular smooth muscle proliferation is helpful to understand the pathophysiological mechanism of vascular proliferative diseases.This article reviews the research progresses in the proliferation of vascular smooth muscle cells by programmed cell death.

关 键 词：凋亡 自噬 焦亡 铁凋亡 血管平滑肌 增殖 

分 类 号：R54[医药卫生—心血管疾病] R363[医药卫生—内科学]