Efficient Knoevenagel condensation catalyzed by imidazole-based halogenfree deep eutectic solvent at room temperature  

作　　者：Hao Qin Yishan Zhou Qian Zeng Hongye Cheng Lifang Chen Bingjian Zhang Zhiwen Qi 

机构地区：[1]Max Planck Partner Group at the State Key Laboratory of Chemical Engineering,School of Chemical Engineering,East China University of Science and Technology,130 Meilong Road,Shanghai,200237,China [2]School of Chemical Engineering and Technology,Sun Yat-Sen University,135 Xingang West Road,Guangzhou,510275,China

出　　处：《Green Energy & Environment》2020年第2期124-129,共6页绿色能源与环境（英文版）

基　　金：The financial support from National Natural Science Foundation of China(21576081,21776074 and 2181101120)is greatly acknowledged.

摘　　要：For the first time,we employed the halogen-free deep eutectic solvent(DES)into the Knoevenagel condensation between aromatic aldehydes and active methylene compounds at room temperature.The DESs[3Im:PTSA]and[4Im:PTSA]were prepared by imidazole(Im)and p-tol-uenesulfonic acid(PTSA),which were experimentally screened from a series of organic acids with imidazole.a,b-Unsaturated carbonyl compounds were obtained in good to excellent yields under solvent-free conditions with fast reaction rate.These two DESs can be reused for multiple times with no loss of catalytic activity.

关 键 词：Halogen-free DES Knoevenagel condensation Room temperature Recyclable catalyst Solvent-free condition 

分 类 号：O621.251[理学—有机化学]