香豆素三唑两亲化合物的合成及其载药和Fe^3+识别性能研究  

Synthesis of coumarin triazole amphiphile and its drug load and Fe^3+ recognition properties

作　　者：张得灵 常清 余娟 葛涛 程晓红[1] ZHANG De-ling;CHANG Qing;YU Juan;GE Tao;CHENG Xiao-hong(Key Laboratory of Medicinal Chemistry for Natural Resources,School of Chemiscal Science and Technology,Yunnan University,Kunming 650091,China;State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming 650000,China)

机构地区：[1]云南大学,教育部自然资源药物化学重点实验室,化学科学与工程学院,云南昆明650091 [2]稀贵金属综合利用新技术国家重点实验室,云南昆明650000

出　　处：《云南大学学报（自然科学版）》2020年第6期1166-1172,共7页Journal of Yunnan University(Natural Sciences Edition)

基　　金：国家自然科学基金(21865038,21602195);云南省高校创新团队(2018FY001(-012));稀贵金属综合利用新技术国家重点实验室开放课题(SKL-SPM-201812).

摘　　要：以Click反应为关键步骤合成了一个以香豆素为中心核,两侧为三唑多醚链树枝体的多链形分子CTE,CTE的结构通过1H NMR,13C NMR及元素分析进行了确认.用CTE制备了载有鬼臼毒素的胶束,测得胶束的临界质量浓度、载药量和包封率.结果表明,CTE分子形成的胶束对鬼臼毒素的包封率为56.7%,载药量为34.0%;此外化合物CTE对Fe^3+具有优异的识别作用,可用于检测Fe^3+金属离子的化学传感器.In this paper,a polycatenar molecular CTE with coumarin as the central core and triazole PEO dendrons at both sides was synthesized by Click reaction.The structure of CTE was confirmed by 1H NMR,13C NMR and elemental analysis.The CTE micelles loaded with podophyllotoxin were prepared.The critical micelle concentration,drug load and encapsulation efficiency were measured.The results showed that the encapsulation efficiency of the CTE micelles to podophyllotox in was 56.7%,and the drug load was 34.0%.In addition,CTE showed excellent selectivity to Fe^3+ among a series of cations,which could be used as chemosensor against Fe^3+.

关 键 词：香豆素 多醚链 鬼臼毒素 胶束 离子识别 

分 类 号：O633.5[理学—高分子化学]