香丹注射液联合激素治疗肾病综合征临床研究  

Clinical Study on Xiangdan Injection Combined with Hormones for Nephrotic Syndrome

作　　者：栗文杰 应雄 陈小莉 LI Wenjie;YING Xiong;CHEN Xiaoli

机构地区：[1]仙居县中医院,浙江仙居317300

出　　处：《新中医》2020年第21期44-47,共4页New Chinese Medicine

摘　　要：目的:观察香丹注射液联合激素治疗肾病综合征的临床疗效。方法:选取肾病综合征患者114例,按随机数字表法分为对照组和观察组各57例。对照组给予激素治疗,观察组在对照组基础上联合香丹注射液治疗。比较2组浮肿、腰痛、疲乏等中医症状评分;检测血尿素氮(BUN)、肌酐(SCr)、24 h尿蛋白定量、纤维蛋白原(FIB)、血浆黏度(PV)水平;比较2组临床疗效与不良反应发生率。结果:治疗前,2组浮肿、腰痛、疲乏评分比较,差异无统计学意义(P>0.05)。治疗后,2组浮肿、腰痛、疲乏评分较治疗前降低(P<0.05),且观察组浮肿、腰痛、疲乏评分均低于对照组(P<0.05)。治疗前,2组BUN、SCr、24 h尿蛋白定量比较,差异无统计学意义(P>0.05)。治疗后,2组BUN、SCr、24 h尿蛋白定量较治疗前降低(P<0.05),且观察组BUN、SCr、24 h尿蛋白定量均低于对照组(P<0.05)。治疗前,2组FIB、PV水平比较,差异无统计学意义(P>0.05)。治疗后,2组FIB、PV水平较治疗前降低(P<0.05),且观察组FIB、PV水平低于对照组(P<0.05)。观察组总有效率为94.74%,高于对照组71.93%(P<0.05)。观察组不良反应发生率为7.02%,低于对照组33.33%(P<0.05)。结论:香丹注射液联合激素治疗肾病综合征患者效果显著,可以改善肾功能和血液流变学指标。Objective: To observe the clinical effect of Xiangdan injection combined with hormones for nephrotic syndrome. Methods:A total of 114 cases of patients with nephrotic syndrome were selected and divided into the control group and the observation group according to the random number table method,57 cases in each group. The control group was given hormones, and the observation group was additionally given Xiangdan injection based on the treatment of the control group. The Chinese medicine syndrome scores such as edema,the lumbar pain and fatigue were compared between the two groups;the contents of blood urea nitrogen(BUN),serum creatinine(SCr) and 24-hour urine protein ratio as well as the levels of fibrinogen(FIB) and plasma viscosity(PV) were detected. The clinical effect and the incidence of adverse reactions were compared between the two groups. Results:Before treatment,when compared the scores of edema,the lumbar pain and fatigue between the two groups,there was no significance in the difference(P>0.05). After treatment,the scores of edema, the lumbar pain and fatigue in the two groups were decreased when compared with those before treatment(P<0.05);the above three scores in the observation group were lower than those in the control group(P<0.05). Before treatment,when compared the contents of BUN,SCr and 24-hour urine protein between the two groups,there was no significance in the difference(P>0.05). After treatment, the contents of BUN, SCr and 24-hour urine protein in the two groups were decreased when compared with those before treatment(P<0.05);the above three contents in the observation group were lower than those in the control group(P<0.05). Before treatment, when compared the levels of FIB and PV between the two groups,there was no significance in the difference(P>0.05). After treatment,the levels of FIB and PV in the two groups were decreased when compared with those before treatment(P<0.05);the above two levels in the observation group were lower than those in the control group(P<0.05). The total eff

关 键 词：肾病综合征 香丹注射液 激素 肾功能 血液流变学 不良反应 

分 类 号：R692[医药卫生—泌尿科学]