癃闭舒胶囊联合多沙唑嗪治疗前列腺增生症临床研究  

Clinical Study on Longbishu Capsules Combined with Doxazosin for Benign Prostatic Hyperplasia

作　　者：路宏召 李兴阳 刘军胜[3] LU Hongzhao;LI Xingyang;LIU Junsheng

机构地区：[1]郏县人民医院外四科,河南郏县467100 [2]郏县人民医院内科,河南郏县467100 [3]郏县中医院外一科,河南郏县467100

出　　处：《新中医》2020年第21期48-50,共3页New Chinese Medicine

摘　　要：目的:观察癃闭舒胶囊联合多沙唑嗪治疗前列腺增生症(BPH)的临床疗效。方法:将BPH患者110例随机分为对照组与观察组,每组55例。对照组采用甲磺酸多沙唑嗪片治疗,观察组在对照组的基础上加服癃闭舒胶囊治疗。观察比较2组治疗前后国际前列腺症状评分(IPSS)、生活质量评分(QOL)、最大尿流率(Qmax)、残余尿量及前列腺体积的变化,并统计2组总体临床疗效及不良反应发生率。结果:总有效率观察组为76.36%,对照组为54.55%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者IPSS评分、QOL评分均较治疗前明显降低(P<0.05),Qmax值较治疗前明显升高(P<0.05);且观察组各项指标改善较对照组更显著(P<0.05)。治疗后,2组患者残余尿量、前列腺体积均较治疗前明显减少(P<0.05),且观察组两项指标改善较对照组更显著(P<0.05)。不良反应发生率观察组为33.64%,对照组为18.18%,2组比较,差异有统计学意义(P<0.05)。结论:癃闭舒胶囊联合甲磺酸多沙唑嗪片治疗BPH,可有效缩小前列腺体积,改善阻塞症状,减少尿残留,增大尿流率,且不良反应较少,总体疗效优于单纯西药治疗。Objective:To observe the clinical effect of Longbishu capsules combined with doxazosin for benign prostatic hyperplasia(BPH). Methods: A total of 110 cases of BPH patients were randomly divided into the control group and the observation group,55 cases in each group. The control group was given doxazosin mesylate tablets,and the observation group was additionally given the oral administration of Longbishu capsules based on the treatment of the control group. Before and after treatment, the changes in scores of International Prostate Symptom Score(IPSS) and quality of life(QOL),maximum urinary flow rate(Qmax),volume of postvoid residual urine,and the prostate volume were observed and compared in the two groups. The total clinical effect and the incidence of adverse reactions were counted in the two groups. Results:The total effective rate was 76.36% in the observation group, and 54.55% in the control group, the difference being significant(P<0.05). After treatment, the scores of IPSS and QOL in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the Qmax was significantly increased when compared with that before treatment(P<0.05);the improvement of the indexes above in the observation group was more significant than that in the control group(P<0.05). After treatment,the volume of postvoid residual urine and the prostate volume in the two groups was significantly decreased when compared with that before treatment(P<0.05);the improvement of the indexes above in the observation group was more significant than that in the control group(P<0.05). The incidence of adverse reactions was33.64% in the observation group,and 18.18% in the control group,the difference being significant(P<0.05). Conclusion:In the treatment of BPH,the therapy of Longbishu capsules combined with doxazosin mesylate tablets can effectively narrow the prostate volume,relieve obstructive symptoms,reduce postvoid residual urine,and increase urinary flow rate,with lesser adverse reactions;its total curative

关 键 词：前列腺增生症 甲磺酸多沙唑嗪片 癃闭舒胶囊 

分 类 号：R697.32[医药卫生—泌尿科学]