四红祛斑汤联合氢醌霜治疗黄褐斑临床研究  

Clinical Study on Sihong Quban Tang Combined with Hydroquinone Cream for Chloasma

作　　者：沈安强[1] 王小勇[1] 袁丞达[1] SHEN Anqiang;WANG Xiaoyong;YUAN Chengda

机构地区：[1]杭州市中医院丁桥院区皮肤科,浙江杭州310016

出　　处：《新中医》2020年第21期78-80,共3页New Chinese Medicine

摘　　要：目的:观察四红祛斑汤联合氢醌霜治疗黄褐斑的临床效果。方法:将82例黄褐斑患者随机分为对照组与观察组,每组41例。对照组应用氢醌霜涂抹治疗,观察组给予四红祛斑汤内服联合氢醌霜涂抹治疗。比较2组治疗前后皮肤状态(皮肤含水量与弹性)、氧化指标[一氧化氮(NO)、超氧化物歧化酶(SOD)]水平变化,统计2组总体临床疗效以及不良反应情况。结果:总有效率观察组为90.24%,对照组为68.29%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者皮肤含水量、皮肤弹性均较治疗前增加(P<0.05),且观察组2项指标改善较对照组更显著(P<0.05)。治疗后,2组患者NO水平较治疗前降低(P<0.05),SOD水平升高(P<0.05);且观察组2项指标改善较对照组更显著(P<0.05)。不良反应发生率观察组为3.64%,对照组为20.00%,2组比较,差异有统计学意义(P<0.05)。结论:四红祛斑汤联合氢醌霜治疗黄褐斑,可有效改善患者皮肤状态,减缓患者皮肤衰老,更好的保证皮肤光泽,且安全性更好,疗效优于单纯西药治疗。Objective: To observe the clinical effect of Sihong Quban tang combined with hydroquinone cream for chloasma. Methods: A total of 82 cases of patients with chloasma were randomly divided into the control group and the observation group,41 cases in each group. The control group was treated with hydroquinone cream,and the observation group was additionally given oral administration of Sihong Quban tang based on the treatment of the control group. The changes in skin condition(water content and elasticity of skin),and the levels of nitric oxide(NO) and superoxide dismutase(SOD) before and after treatment were compared between the two groups. The total clinical effect and the incidence of adverse reactions were counted in the two groups. Results:The total effective rate was 90.24% in the observation group,and 68.29% in the control group,the difference being significant(P<0.05). After treatment,the water content and elasticity of skin in the two groups were increased when compared with those before treatment(P<0.05),and the improvement of the two indexes in the observation group was more significant than that in the control group(P<0.05). After treatment,the levels of NO in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of SOD were increased(P<0.05);the improvement of above two indexes in the observation group was more significant than that in the control group(P<0.05). The total incidence of adverse reactions was 3.64% in the observation group, and 20.00% in the control group,the difference being significant(P<0.05). Conclusion:In the treatment of chloasma,the therapy of Sihong Quban tang combined with hydroquinone cream has better curative effect and safety than that of simple western medicine. It can effectively improve skin condition,slow down skin ageing,and keep the skin glowing.

关 键 词：黄褐斑 四红祛斑汤 氢醌霜 一氧化氮 超氧化物歧化酶 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]