局部走罐联合刺血拔罐疗法对寻常型银屑病的疗效及血清HPA、VEGF水平的影响  

Curative Effect of Local Sliding-Cupping Combined with Bleeding-Cupping Therapy on Psoriasis Vulgaris and Its Effect on Levels of HPA and VEGF in Serum

作　　者：金梦祝 曹庆科 李胜华 吴云 陈峰 殷文浩 JIN Mengzhu;CAO Qingke;LI Shenghua;WU Yun;CHEN Feng;YIN Wenhao

机构地区：[1]嘉兴市第一医院,浙江嘉兴

出　　处：《新中医》2020年第21期84-87,共4页New Chinese Medicine

基　　金：浙江省中医药科技计划项目(2015ZB114);嘉兴市中医药重点学科项目-中西医结合皮肤病与性病学(2019XK-C06)。

摘　　要：目的:观察局部走罐联合刺血拔罐疗法治疗寻常型银屑病的临床疗效及患者治疗前后血清肝素酶(HPA)、血管内皮生长因子(VEGF)水平的变化。方法:将90例寻常型银屑病患者随机分为常规治疗组、走罐组及联合治疗组,每组30例。常规治疗组给予窄谱中波紫外线(NB-UVB)照射联合外用哈西奈德乳膏治疗,走罐组给予局部走罐联合刺血拔罐疗法治疗,联合治疗组同时采用上述2组的治疗方案,3组均治疗8周。观察3组临床疗效并检测治疗前后血清HPA、VEGF水平。结果:联合治疗组愈显率为86.67%,走罐组愈显率为56.67%,常规治疗组愈显率为63.33%。联合治疗组愈显率高于走罐组及常规治疗组(P<0.05)。常规治疗组愈显率与走罐组愈显率比较,差异无统计学意义(P>0.05)。治疗后,3组血清HPA、VEGF水平均较治疗前降低(P<0.05);联合治疗组血清HPA、VEGF水平均较走罐组及常规治疗组降低更明显(P<0.05);常规治疗组HPA、VEGF水平与走罐组比较,差异均无统计学意义(P>0.05)。结论:局部走罐联合刺血拔罐疗法治疗寻常型银屑病可提高临床疗效,其作用机制可能与降低血清HPA、VEGF水平有关。Objective:To observe the clinical effect of local sliding-cupping combined with bleeding-cupping therapy on psoriasis vulgaris and the changes in the levels of heparanase(HPA) and vascular endothelial growth factor(VEGF) in serum before and after treatment. Methods: A total of 90 patients with psoriasis vulgaris were randomly divided into the conventional treatment group, the cupping group and the combined treatment group, 30 patients in each group. The conventional treatment group was given irradiation of narrowband ultraviolet B(NB-UVB) combined with external application of Hasinade cream;the cupping group was treated with local sliding-cupping combined with bleeding-cupping therapy;the combined treatment group was treated with the above two treatment schemes simultaneously. The three groups were treated for eight weeks. The clinical effect in the three groups was observed and HPA and VEGF levels in serum were measured before and after treatment. Results:The markedly effective rate was 86.67% in the combined treatment group,56.67% in the cupping group,and 63.33% in the conventional treatment group. The combined treatment group had higher markedly effective rate than the cupping group and the conventional treatment group(P<0.05). There was no significant difference in the comparison of markedly effective rate between the conventional treatment group and the cupping group(P>0.05). After treatment,the levels of HPA and VEGF in serum in the three groups were all decreased when compared with those before treatment(P<0.05);the levels of HPA and VEGF in serum in the combined treatment group were decreased more significantly than those in the conventional treatment group and the cupping group(P<0.05). There were no significant differences in the comparison of HPA and VEGF levels between the conventional treatment group and the cupping group(P>0.05). Conclusion: Local sliding-cupping combined with bleeding-cupping can improve the clinical therapeutic effect on psoriasis vulgaris,and its mechanism may be related to the r

关 键 词：寻常型银屑病 走罐 刺血拔罐疗法 窄谱中波紫外线 哈西奈德乳膏 肝素酶 血管内皮生长因子 

分 类 号：R275.9[医药卫生—中西医结合] R244.3[医药卫生—中医皮科]