锰离子作为免疫调节剂的发现及应用展望  

The Discovery and Prospect of Manganese (Mn)-Dependent Immunomodulation

作　　者：卫潇茗 王晨光 张睿 蒋争凡[1,2] WEI Xiaoming;WANG Chenguang;ZHANG Rui;JIANG Zhengfan(Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education,School of Life Sciences,Peking University,Beijing 100871,China;Peking-Tsinghua Center for Life Sciences,Peking University,Beijing 100871,China)

机构地区：[1]北京大学生命科学学院,细胞分化与增殖教育部重点实验室,北京100871 [2]北大–清华生命科学联合中心,北京100871

出　　处：《中国细胞生物学学报》2020年第10期1721-1731,共11页Chinese Journal of Cell Biology

基　　金：国家自然科学基金委重点项目(批准号:31830022)资助的课题。

摘　　要：金属元素是生命体中的重要成分。近年来,金属免疫学的发展令人瞩目,其广度和深度正在被快速地拓宽和挖掘。锰元素是金属免疫学研究领域中的后起之秀,越来越多的研究表明,锰(离子)在免疫系统中扮演了很重要的角色,锰离子所具有的免疫调控功能相当丰富,其作用被大大低估。现有的研究结果提示,锰离子在营养免疫和天然免疫等过程中发挥功能。该文对于锰金属免疫学进行了详述,从多个层面介绍并分析了锰离子的免疫调控功能,提出了锰离子作为细胞危险相关分子模式的工作模型,并总结和展望了基于锰离子免疫调控功能而发展出的现有的及未来可能的不同应用。Metals are essential components of all living beings.The progress of metalloimmunology has been remarkable in recent years,in which the breadth and depth are being explored rapidly.Manganese is a promising member in the field of metalloimmunology.Increasing studies indicate that manganese (Mn2+) plays an indispensable role in the immune system with its actual immunomodulatory effects vastly underestimated.Available research results show that manganese (Mn2+) not only functions in nutritional immunity,but also in innate immunity and so on.This review introduces manganese metalloimmunology in detail,analyses Mn2+-dependent immunomodulation in multi-aspects,proposes a working model for Mn2+ acting as a new member of DAMPs (danger-associated molecular patterns),and discusses the future immunomodulatory application of Mn2+.

关 键 词：锰离子 免疫调控 天然免疫 抗病毒 cGAS-STING通路 危险相关分子模式 佐剂 肿瘤免疫疗法 

分 类 号：R392[医药卫生—免疫学]