COPD患者血清IL-6、CRP、血浆NT-proBNP与肺功能的相关性及其对病情的预测价值  

Correlation between serum IL-6,CRP,plasma NT-proBNP and pulmonary function in patients with COPD and its predictive value

作　　者：杨文漪 王金湖[1] 曹季军[1] 许爱萍[1] 李勇[1] YANG Wenyi;WANG Jinhu△;CAO Jijun;XU Aiping;LI Yong(Department of Clinical Laboratory,Taicang First People's Hospital,Suzhou,Jiangsu 215400,China)

机构地区：[1]太仓市第一人民医院检验科,江苏苏州215400

出　　处：《检验医学与临床》2020年第23期3459-3462,共4页Laboratory Medicine and Clinic

摘　　要：目的分析慢性阻塞性肺疾病(COPD)稳定期患者血清白细胞介素-6(IL-6)、C反应蛋白(CRP)及血浆氨基末端脑钠肽前体(NT-proBNP)与肺功能的相关性及其对病情的预测价值。方法选取2018年1月至2019年12月98例该院收治的COPD患者,根据患者的病情程度分为稳定期组(50例)和急性加重期组(48例),并根据患者的预后情况将稳定期组患者分为预后良好组(27例)和预后不良组(23例)。各组血清IL-6、CRP、血浆NT-proBNP及肺功能指标水平进行比较,并分析COPD稳定期患者血清IL-6、CRP、血浆NT-proBNP与肺功能相关性。结果稳定期组患者血清IL-6、CRP、血浆NT-proBNP与肺功能指标均明显优于急性加重期组,预后良好组血清IL-6、CRP、血浆NT-proBNP与肺功能指标均明显优于预后不良组,差异均有统计学意义(P<0.05);COPD稳定期患者血清IL-6、CRP、血浆NT-proBNP水平与肺功能状况呈负相关。受试者工作特征曲线(ROC曲线)分析显示,IL-6、CRP、NT-proBNP、肺活量(FVC)、呼吸峰值流速(PEF)、第1秒用力呼气量(FEV1)预测对预后良好患者的曲线下面积(AUC)分别为0.730、0.940、0.899、0.907、0.890、0.845。结论COPD稳定期患者血清IL-6、CRP、血浆NT-proBNP与肺功能状况明显优于COPD急性加重期患者,且CRP、FVC对COPD患者的预后预测价值较高。Objective To analyze the correlation between serum interleukin-6;(IL-6),C reactive protein(CRP),plasma N-terminal pro brain natriuretic peptide(NT-proBNP)and pulmonary function and its predictive value in patients with chronic obstructive pulmonary disease(COPD).Methods Totally 98 patients with COPD in the hospital from January 2018 to December 2019 were selected According to the severity of the disease,the patients were divided into the stable stage group(50 cases)and the acute exacerbation group(48 cases),and according to the prognosis of the patients,the stable stage group was divided into the group with good prognosis(27 cases)and the group with poor prognosis(23 cases).The differences of serum IL-6,CRP,plasma NT-proBNP and pulmonary function indicators in different groups were compared,and the correlation between serum IL-6,CRP,plasma NT-proBNP and pulmonary function indicators was analyzed in COPD stable stage patients.Results Serum IL-6,CRP,plasma NT-proBNP and pulmonary function indicators were significantly better than those in the acute exacerbation group,and serum IL-6,CRP,plasma NT-proBNP and pulmonary function indicators in the group with good prognosis were significantly better than those in the group with poor prognosis(P<0.05).ROC curve analysis showed that the AUC of IL-6,CRP,NT-proBNP,FVC,PEF and FEV1 for patients with good prognosis were 0.730,0.940,0.899,0.907,0.890 and 0.845,respectively.Conclusion Serum IL-6,CRP,plasma NT-proBNP and pulmonary function status in patients with COPD at stable stage were significantly better than those in patients with acute exacerbation,and CRP and FVC had higher prognostic value for COPD patients.

关 键 词：慢性阻塞性肺疾病 白细胞介素-6 C反应蛋白 氨基末端脑钠肽前体 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]