Synergistic Catalysis of Se and Cu for the Activation of α-H of Methyl Ketones with Molecular Oxygen/Alcohol to Produce α-Keto Acetals  

作　　者：Chao Chen Zhicheng Cao Xu Zhang Yiming Li Lei Yu Xuefeng Jiang 

机构地区：[1]School of Chemistry and Chemical Engineering,Yangzhou University,Yangzhou,Jiangsu 225002,China [2]'Shanghai Key Laborotory of Green Chemistry and Chemical Process,Department of Chemistry,East China Normal University,Shanghai 200062,China

出　　处：《Chinese Journal of Chemistry》2020年第10期1045-1051,共7页中国化学（英文版）

基　　金：We thank the Natural Science Foundation of Jiangsu Province(BK20181449);the Jiangsu Provincial Six Talent Peaks Project(XCL-090),the National Natural Science Foundation of China(Nos.21202141,21971065);the Priority Academic Program Devel-opment(PAPD)of Jiangsu Higher Education Institutions.

摘　　要：Summary of main observation and conclusion Selenium and copper synergistically catalyzed the oxidation/alkoxylation of methyl ketones to synthesize a-keto acetals directly.Using 02 as oxidant and alcohol as solvent and alkoxylation reagent,the reaction is practical from industrial viewpoint.Mechanistic studies revealed that copper promoted the oxidation of organoselenium intermediates with O2 to allow the key rearrangement and selenoxide syn-elim-ination regenerating the catalytically active organoselenium species.

关 键 词：copper organo OXYGEN 

分 类 号：O62[理学—有机化学]