Zinc Powder Catalysed Formylation and Urealation of Amines Using CO2 as a C1 Building Block  

作　　者：Chongyang Du Yaofeng Chen 

机构地区：[1]State Key Laboratory of Organometllic Chemistry,Shanghai Institute of Organic Chemistry,University of chinese Academy of Sciences,Chinese Academy of Sciences,345 Lingling Road,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2020年第10期1057-1064,共8页中国化学（英文版）

基　　金：We acknowledge financial support from the National Natural Science Foundation of China(Nos.21732007 and 21821002);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000);Fujian Institute of Innovation,Chinese Academy of Sciences.

摘　　要：Summary of main observation and conclusion Transformation of CO2 into valuable organic compounds catalysed by cheap and biocompatible metal I catalysts is one of important topics of current organic synthesis and catalysis.Herein,we report the zinc powder catalysed formylation and urealation of amines with CO2 and(EtO)zSiH under solvent free condition.Using 2 mol%zinc powder as the catalyst,a series of secondary amines,both the aromatic ones and the aliphatic ones,can be formylated into formamides.When primary aromatic amines were used as the substrates,the reactions produce urea derivatives.The electronic and steric effects from the substrates on the formylation and urealation reactions were observed and discussed.The recovery and reusability of zinc powder were investigated,showing the zinc powder can be reused in the formylation reaction without loss of catalytic activity.The analysis on the reactants/products mixture after filtering out the zinc powder showed the zinc concentration in the mixture is low to 1 ppm.The path-ways for the formylation and urealation of amines with this catalytic system were also investigated,and related to the different substrates.

关 键 词：AMINES AROMATIC MIXTURE 

分 类 号：O62[理学—有机化学]