Electrochemical Dearomative Halocyclization of Tryptamine and Tryptophol Derivatives  

作　　者：Kun Liu Yuqi Deng Wenxu Song Chunlan Song Aiwen Lei 

机构地区：[1]College of Chemistry ond Molecular Sciences,Institute for Advanced Studies(IAS),Wuhan Univrsity,Wuhon,Hpbei 430072,China

出　　处：《Chinese Journal of Chemistry》2020年第10期1070-1074,共5页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(No.21520102003);the Hubei Province Natural Science Foundation of China(No,2017CFA010);The Pro-gram of Introducing Talents of Discipline to Universities of China(111 Program)is also appreciated.

摘　　要：Summary of main observation and conclusion Owing to the easy functionalization of 3-haloindolines to many biologically active compounds,extensive efforts have been made for their efficient preparation.Herein,an electrochemical dearomative bromo-and chloro-cyclization of tryptamine and tryp-tophol derivatives has been developed under undivided electrolytic conditions.In this protocol,neither external chemical oxidants nor harsh conditions are needed,and a wide range of substituted hexahydropyrroloindolines/tetrahydrofuroindolines are obtained with halide ion in high efficiencies.Moreo-ver,this electrolysis could also be scaled up to gram synthesis with good yields.

关 键 词：conditions. CYCLIZATION SUBSTITUTED 

分 类 号：O62[理学—有机化学]