A Journey to SPSiOL,a New Type of Chiral Ligand Scaffold  

作　　者：Hong-Chao Chen Xin Chang 

机构地区：[1]State Key Laboratony of Organometallic Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,Chinese Acodemy of Sciences(CAS),345 Lingling Road,Shanghai 200032,China [2]Deportment of Chemistry,Zhejiang Sci-Tech Univrsity,Xiasha West Higher Education District,Hangzhou,Zhejiong 310018,China

出　　处：《Chinese Journal of Chemistry》2020年第10期1203-1204,共2页中国化学（英文版）

摘　　要：The development of privileged chiral architectures,which are versatile for various chiral ligands or organocatalysts preparation with superior performance in a variety of organic transformations,has significantly pushed forward the advancement of asymmetric catalysis.However,only a few scaffolds could be seen as privileged chiral backbones,including BINOL-,SPINOL-,TADDOL-,quinine-,planar chiral ferrocene-based backbones and others.111 In view of the importance of novel chiral ligand skeletons in asymmetric catalysis,our group came up with a design of Si-centered spirocyclic skeletons,which could serve as a platform for new chiral ligands and organocatalysts preparation.In term of the electronegativity of Si,the longer C-Si bond(C-Si vs.C-C:co 1.87 A vs.ca 1.53 A),bigger atomic radius(Si vs.C:111 pm vs.67 pm),and vertical configuration of Si-centered spirocycles in comparison to C-centered spirocyclic scaffolds/21 the new skeletons might lead to a different reactive behavior in asymmetric catalysis(Scheme 1A).

关 键 词：CHIRAL SKELETON BACKBONE 

分 类 号：O62[理学—有机化学]