中药熏蒸联合补肾强督方加减治疗肾虚督寒型强直性脊柱炎临床研究  

Clinical study on Chinese herbal fumigation combined with Bushen Qiangdu subtracting prescription in treating ankylosing spondylitis with kidney deficiency and governor channel cold type

作　　者：朱峰 郑丹妮 张英泽[2,3] 陶庆文 赵淑欣[2,3] 孔维萍 阎小萍[2,3] ZHU Feng;ZHENG Dan-ni;ZHANG Ying-ze;TAO Qing-wen;ZHAO Shu-xin;KONG Wei-ping;YAN Xiao-ping(Graduate School,Beijing University of Chinese Medicine,Beijing 100029,China;Department of Rheumatology,China-Japan Friendship Hospital,Beijing 100029,China;Beijing Key Laboratory of Immune Inflammatory Diseases,Beijing 100029,China)

机构地区：[1]北京中医药大学研究生院,北京100029 [2]中日友好医院中医风湿病科,北京100029 [3]免疫炎性疾病北京市重点实验室,北京100029

出　　处：《中华中医药杂志》2020年第11期5890-5894,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金青年科学基金项目(No.81403378);北京市自然科学基金项目(No.7182148);中日友好医院青年科技英才计划(No.2014-QNYC-B-02)。

摘　　要：目的:观察中药熏蒸联合补肾强督方加减治疗肾虚督寒型强直性脊柱炎的临床疗效。方法:纳入2018年8月至2019年2月于中日友好医院就诊的肾虚督寒型强直性脊柱炎(大偻)患者72例。试验组36例,予以寒痹外用方中药熏蒸联合补肾强督方加减治疗;对照组36例,予以补肾强督方加减口服。收集患者人口学资料。分别测量两组治疗前后脊柱功能指标,同时观察两组治疗前后疾病活动指标及不良反应。结果:对照组共收集病例资料34例,试验组35例。试验组中医疗效总有效率(82.86%)显著高于对照组(58.82%)(P<0.05)。试验组达到ASAS20评价标准的例数为23例,有效率为65.71%;对照组例数为16例,有效率为47.06%。对照组治疗后的中医证候评分、脊柱疼痛评分、患者总体评价(PGA)评分比治疗前减少(P<0.05)。试验组治疗后的中医证候评分、脊柱疼痛评分、强直性脊柱炎疾病活动性指数(BASDAI)、晨僵时间及PGA评分比治疗前均减少(P<0.05)。试验组治疗后中医证候评分及PGA评分低于对照组(P<0.05)。结论:中药熏蒸(寒痹外用方)联合补肾强督方加减内服,内外合治,可有效降低患者中医证候评分、缩短晨僵时间,减低BASDAI及PGA评分,缓解脊柱疼痛,疗效优于单用补肾强督方加减口服。Objective:To observe the clinical efficacy of Chinese herbal fumigation(Cold Bi external prescription)combined with Bushen Qiangdu subtracting prescription in treating ankylosing spondylitis with kidney deficiency and governor channel cold type.Methods:Seventy-two patients with ankylosing spondylitis of kidney deficiency and governor channel cold type in China-Japan Friendship Hospital From August 2018 to February 2019 were enrolled.The patients were randomly divided into experimental group and control group.Thirty-six patients in the experimental group were treated with Chinese herbal fumigation(Cold Bi external prescription)combined with Bushen Qiangdu subtracting prescription.Thirtysix cases in control group were treated with Bushen Qiangdu subtracting prescription.Demographic data were collected.The indexes of spine mobility and disease activity were measured before and after treatment as well as adverse reactions and side effects.Results:In the control group,34 cases were collected.In the experimental group,35 cases were collected.In the experimental group,cases reached the effectiveness and obvious effectiveness of evaluation criteria of curative effect of traditional Chinese medicine(TCM)took account for 82.86%of the total.As for the control group,it was 58.82%,it was significant difference(P<0.05).Twenty-three cases of experimental group reached ASAS20,accounting for 65.71%of the total.In the control group,16 cases reached ASAS20,accounting for 47.06%of the total.The scores of TCM symptoms,scores of spinal pain and PGA in the control group after treatment were lower than those before treatment(P<0.05).The scores of TCM symptoms,spinal pain,BASDAI,morning stiffness and PGA in the experimental group were all lower than those before treatment(P<0.05).Moreover,the experimental group has lower scores of TCM symptoms and PGA than control group after treatment(P<0.05).Conclusion:Using Chinese herbal fumigation(Cold Bi external prescription)combined with Bushen Qiangdu subtracting prescription can effectively red

关 键 词：补肾强督方 临床疗效 强直性脊柱炎 外治法 中药熏蒸 

分 类 号：R259[医药卫生—中西医结合]