肠道菌群——中医药治疗抑郁症的新靶点  

Gut microbiota:A new target of antidepressant of traditional Chinese medicine

作　　者：吴佳佳 陈建北 卞庆来 陈家旭 WU Jia-jia;CHEN Jian-bei;BIAN Qing-lai;CHEN Jia-xu(School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;Formula-Pattern Research Center,School of Traditional Chinese Medicine,Jinan University,Guangzhou 510632,China)

机构地区：[1]北京中医药大学中医学院,北京100029 [2]暨南大学中医学院方证研究中心,广州510632

出　　处：《中华中医药杂志》2020年第10期4930-4933,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金重点项目(No.81630104),国家自然科学基金面上项目(No.81473597)。

摘　　要：抑郁症的发生、发展与微生物-脑-肠轴密切相关,其机制涉及神经内分泌、免疫调节、炎症反应、菌群代谢产物等多个方面。研究表明调节肠道微生态可以影响焦虑或抑郁行为。抑郁症属中医"郁证"范畴,中药复方治疗抑郁症疗效显著,不良反应少,其多成分、多途径、多靶点的协同作用特点与现代肠道微生态理论有很大的趋同性,二者都是立足于整体,对机体产生系统化的影响以维持健康状态。文章拟以肠道菌群为靶点,探讨中医药治疗抑郁症的作用机制,为未来抑郁症的预防和中医药研发提供重要方向。The occurrence and development of depression are closely related to the microbiota-brain-gut axis,and its mechanism involves many aspects such as neuroendocrine,immune regulation,inflammatory response,and metabolites of the flora,and so on.Studies have shown that regulating the intestinal microecology can affect anxiety or depression.Depression belongs to the category of’stagnation syndrome’in traditional Chinese medicine(TCM).TCM has significant effects in treating depression,and it has few adverse reactions.The synergistic characteristics of its multi-component,multi-path,and multi-target are very similar to modern intestinal microecology.Based on the whole concept,there is a systematic impact on the body to maintain a healthy state.This article intended to take the gut microbiota as the target to explore the mechanism of TCM treatment of depression,and it provided an important direction for the prevention of future depression and the development of TCM.

关 键 词：抑郁症 肠道菌群 中药复方 微生物-脑-肠轴 

分 类 号：R277.7[医药卫生—中医学]