Wnt/Retromer信号通路与补肾益精法通过脑-肠轴治疗慢传输型便秘的研究进展  

Research progress of Wnt/Retromer signaling pathway and invigorating the kidney and replenishing essence therapy for slow transit constipation through brain-gut axis

作　　者：闫曙光[1] 惠毅[1] 梁星琛 王郁金[1] 周永学[1] YAN Shu-guang;HUI Yi;LIANG Xing-chen;WANG Yu-jin;ZHOU Yong-xue(Shaanxi University of Chinese Medicine,Shaanxi Provincial Key Laboratory of Gastrointestinal Disease and Syndrome Formulae,Xianyang 712046,China)

机构地区：[1]陕西中医药大学,陕西省胃肠病证方药重点研究室,咸阳712046

出　　处：《中华中医药杂志》2020年第10期5084-5086,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重大科技专项“重大新药创制”项目(No.2012ZX09103201-037);国家自然科学基金面上项目(No.81273663)。

摘　　要：中医补肾益精法是治疗脑神经病变和功能性便秘的常用治法之一,体现了异病同治。脑-肠轴是已被现代医学证实存在于大脑和肠道之间的双向信号调节系统,Wnt/Retromer信号通路是最近研究发现的大脑神经细胞与肠道细胞之间的"传令兵",是脑-肠轴的物质基础之一。文章拟从Wnt/Retromer信号通路探讨补肾益精法通过脑-肠轴治疗慢传输型便秘的作用机制,为慢传输型便秘的机制研究和治疗提供参考,为研究补肾益精法脑肠同治的科学内涵提供思路。The invigorating the kidney and replenishing essence therapy of traditional Chinese medicine is one of the common treatments methods for the cerebral neuropathy and functional constipation.And it is a reflection of treating different diseases with same method.The brain-gut axis is a two-way signal regulation system between brain and intestine that has been proved by modern medicine.The Wnt/Retromer signaling pathway is recently identified as’messengers’between brain nerve cells and intestinal cells,which is one of the material bases of the brain-gut axis.In this paper,the Wnt/Retromer signaling pathway was used to investigate the mechanism of invigorating the kidney and replenishing essence therapy in the treatment of slow transit constipation by brain-gut axis.It provides the scientific connotation for the study of invigorating the kidney and replenishing essence therapy for the treatment of brain and intestine diseases.

关 键 词：慢传输型便秘 Wnt/Retromer信号通路 脑-肠轴 补肾益精法 线粒体 脑肠同治 进展 

分 类 号：R256.35[医药卫生—中医内科学]