中药合剂对皮肤浅部真菌病致病菌作用的现况  

Present situation of the effects of traditional Chinese medicine mixture on the pathogenic bacteria of superficial dermatomycosis

作　　者：刘登宇 吴建美 曲琳 LIU Dengyu;WU Jianmei;QU Lin(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou Inner Mengolia 014000,China;不详)

机构地区：[1]内蒙古科技大学包头医学院,内蒙古包头014000 [2]内蒙古综合疾病预防控制中心

出　　处：《医学动物防制》2020年第12期1161-1163,共3页Journal of Medical Pest Control

基　　金：内蒙古自治区卫生计生委医疗卫生计生科研计划项目(201802117);内蒙古自治区医疗卫生毒理学重点实验室。

摘　　要：皮肤浅部真菌病在我国流行范围广,是一种常见病,发病几率高。目前用来治疗皮肤浅部真菌病的药效果虽好但是副作用大、易出现耐药性,而中药制剂对皮肤浅部致病真菌有抑制作用,药效好,不易出现耐药性,对人体的副作用小。而且中药价格相对便宜,对皮肤浅部真菌病致病菌有长期且预防性的作用。本文采用高通量测序技术研究中药制剂对致病菌的抑制效果,发现其信号通路,进一步筛选中药中对皮肤浅部真菌病致病菌的成分、提高靶向治疗皮肤浅部真菌病的治疗效果,为临床治疗真菌新药提供理论依据。Superficial dermatomycosis,a common disease with high incidence,is widely popular in China.At present,the medicines used in the treatment of superficial dermatomycosis have good effect,but they are also with large side effects and prone to drug resistance.The traditional Chinese medicine mixture has greatly inhibitory effect on superficial dermatomycosis.It is not prone to drug resistance and has small side effects on human body.Moreover,traditional Chinese medicine is relatively cheap and has a long-term preventive effect on the pathogenic bacteria of superficial dermatomycosis.In this study,high throughput sequencing technology is used to investigate the inhibitory effect of traditional Chinese medicine preparation on pathogenic bacteria to find its signal pathway and further screen the components of traditional Chinese medicine that have effects on pathogenic bacteria of superficial dermatomycosis,in order to improve the therapeutic effect of targeted treatment of superficial dermatomycosis and provide a theoretical basis for new fungal drugs in clinical treatment.

关 键 词：中药合剂 皮肤浅部真菌病致病菌 高通量测序技术 信号通路 治疗效果 

分 类 号：R285[医药卫生—中药学] R756[医药卫生—中医学]