老年患者全身麻醉后苏醒延迟机制研究进展  

Research progress on the mechanism of delayed emergence from general anesthesia in elderly patient

作　　者：胡浪 张益 Hu Lang;Zhang Yi(Department of Anesthesiology,the Second Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563099,China;Guizhou Key Laboratory of Anesthesia and Organ Protection,Zunyi Guizhou 563099,China;School of Anesthesiology,Zunyi Medical University,Zunyi Guizhou 563099,China)

机构地区：[1]遵义医科大学第二附属医院麻醉科,贵州遵义563099 [2]贵州省麻醉与器官保护重点实验室,贵州遵义563099 [3]遵义医科大学麻醉医学院,贵州遵义563099

出　　处：《遵义医科大学学报》2020年第5期673-678,共6页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:81560237);国家自然科学基金资助项目(NO:81860204)。

摘　　要：老年患者麻醉后易发生苏醒延迟,严重影响术后恢复质量,延长住院时间。然而,其发生机制及危险因素目前尚不明确。本文从药代动力学、药效学以及围术期危险因素等方面综述老年患者麻醉后苏醒延迟的可能机制及其最新进展,为全身麻醉后苏醒延迟的研究及提高老年患者术后生活质量提供理论参考。Delayed emergence from general anesthesia tends to occur in the elderly patients,which affects severely the postoperative recovery quality and prolongs the hospital stay.However,the underlying mechanism and potential risk factors is currently less known.From the perspectives of pharmacokinetics,pharmacodynamics and perioperative risk factors,the present review summarizes the possible mechanisms and latest developments of delayed emergence from anesthesia in elderly patients.Also,this review will provide a theoretical reference for improving strategy of geriatric anesthesia,optimizing the utilization of anesthetics,preventing the complications related to delayed emergence and ameliorating postoperative recovery quality in elderly patient.

关 键 词：老年患者 全身麻醉 苏醒延迟 机制 

分 类 号：R614.2[医药卫生—麻醉学]