补肾化痰法治疗多囊卵巢综合征研究进展  

Research Progress in the Treatment of Polycystic Ovary Syndrome by Invigorating the Kidney and Resolving Phlegm

作　　者：孟家宁 王昕[2] MENG Jianing;WANG Xin(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《实用中医内科杂志》2020年第11期18-22,共5页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家中医药管理局项目(JDZX2015064);中医药行业科研专项基金项目(201407001-7);中医药临床学(专)科能力建设基金资助项目(2018-125)。

摘　　要：多囊卵巢综合征(polycystic ovarian syndrome,PCOS)是育龄期妇女常见的生殖内分泌疾病,以生殖和代谢异常为主要特征,临床表现为月经失调、不孕、多毛、痤疮、肥胖、黑棘皮病,其具体病因尚未可知,可能与遗传基因和环境因素有关。PCOS早期可并发不孕症,远期可合并代谢紊乱、心脑血管疾病、子宫内膜癌、卵巢癌等。西医治疗PCOS常为对症治疗,主要有达英-35、二甲双胍、噻唑烷二酮等药物,这些都具有一定的不良反应,不能作为长期服用的治疗药物而不易被患者接受。近年来对于PCOS的中医药研究较多,且治疗效果显著,其中肾虚痰湿证为PCOS患者临床中最为常见的证型,故补肾化痰法为其治疗的根本方法而被广泛应用于临床。文章分析汇总近年来国内国外文献,从炎症因子、氧化应激、细胞凋亡、脂肪因子、糖代谢、卵巢功能、激素水平、子宫内膜厚度角度,基于补肾化痰法探讨PCOS的治疗和作用机制,以期对今后的临床研究提供相应的参考。polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women of childbearing age,which is characterized by abnormal reproduction and metabolism. In recent years,there are many researches on traditional Chinese medicine of PCOS,and the therapeutic effect is significant. The pathogenesis of PCOS is closely related to inflammatory factors,oxidative stress,apoptosis and so on. Kidney deficiency and phlegm dampness type is the most common type of PCOS,and kidney nourishing and phlegm resolving method is widely used in the clinical treatment. This paper analyzes and summarizes the domestic and foreign literature in recent years,and discusses the treatment and mechanism of PCOS based on kidney nourishing and phlegm resolving method,in order to provide the corresponding reference for the future experimental research.

关 键 词：多囊卵巢综合征 补肾化痰 肾虚痰湿 中医药 研究进展 细胞因子 糖脂代谢 卵巢功能 

分 类 号：R271.9[医药卫生—中西医结合]