益气调脂治疗2型糖尿病合并血脂异常临床疗效观察  

Clinical Observation on Yiqi Tiaozhi Recipe in 项 Treatment of Type 2 Diabetes with Dyslipidemia

作　　者：钱逸 李妍蓉 晋玉梅 祖建国 陈洁 QIAN Yi;LI Yanrong;JIN Yumei;ZU Jianguo;CHEN Jie(Shanghai Fengxian District Hospital of Traditional Chinese Medicine,Shanghai 201499,China)

机构地区：[1]上海市奉贤区中医医院,上海201499

出　　处：《实用中医内科杂志》2020年第11期45-48,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：上海市奉贤区科学技术委员会科学技术发展基金(奉科20151213)。

摘　　要：目的探讨益气调脂方治疗2型糖尿病(T2DM)合并血脂异常证属脾虚痰阻兼有血瘀证患者的临床疗效。方法将2016年5月-2019年5月于上海市奉贤区中医医院住院和门诊就诊,且符合T2DM合并血脂异常(证属脾虚痰阻兼有血瘀证)入选标准的120例患者随机分为3组,每组各40例,其中对照组应用单纯西药治疗,阴性对照组在对照组的基础上联合温水200 mL早晚分服,治疗组为在对照组基础上联用益气调脂方浓煎液200 mL早晚分服,在试验过程中原有降糖药物治疗方案不变,以维持血糖稳定,疗程持续12周,观察患者治疗前后症状改善情况、血清胆固醇(TC)、血清甘油三酯(TG)水平的变化,同时观察患者不良反应发生情况,评价药物有效性及安全性。结果治疗组总有效率为95.00%(38/40),对照组及阴性对照组总有效率分为52.50%(21/40)、75.00%(30/40)。治疗组与对照组及阴性组总有效率比较,差异有显著性意义(P<0.05),对照组及阴性对照组之间比较,差异无显著性意义(P>0.05)。与治疗前比较,治疗后3组血清TG、TC显著降低(P<0.05);治疗后,治疗组血清TG、TC水平显著低于对照组及阴性对照组(P<0.05)。在试验过程中无不良反应事件发生。结论益气调脂方治疗2型糖尿病伴血脂异常疗效明显优于单用辛伐他汀治疗,且对改善患者的临床症状有显著疗效。Objective To explore the clinical efficacy of Yiqi Tiaozhi Recipe in the treatment of patients with type 2 diabetes mellitus(T2DM)with dyslipidemia and spleen deficiency and phlegm obstruction combined with blood stasis syndrome.Methods A total of 120 patients from May 2016 to May 2019 were admitted to Fengxian District Hospital of Chinese Medicine in Shanghaimet the standard of T2DM combined with dyslipidemia(syndrome of spleen deficiency and phlegm obstruction combined with blood stasis syndrome).There were three groups with 40 cases in each group.The control group was treated with western medicine alone.The negative control group was combined with warm water 200 mL in the morning and evening based on the control group.The treatment group was combined with Yiqi Tiaozhi Recipe concentrated decoction 200 mL in morning and eveningbased on the control group.The original hypoglycemic drug treatment plan remained unchanged during the test to maintain blood sugar stability.The course of treatment lasted 12 weeks,and we observed the improvement of symptoms,serum levels of cholesterol(TC)and triglyceride(TG)were observed.At the same time,adverse reactions and side effectswere observed to evaluate the effectiveness and safety.Results The total effective rate of the treatment group was 95.00%(38/40),and the total effective rates of the control group and the negative control group were divided into 52.50%(21/40)and 75.00%(30/40).There was a significant difference in the total effective rate among the treatment group and the control group and the negative group(P<0.05).There was no significant difference between the control group and the negative control group(P>0.05).Compared with those before treatment,serum levels of TG and TC in the three groups were significantly reduced after treatment(P<0.05).After treatment,serum levels of TG and TC in the treatment group were significantly lower than those in the control group and the negative control group(P<0.05).No adverse events occurred during the trial.Conclusion Yiqi Tiaozhi

关 键 词：益气调脂方 2型糖尿病 混合性血脂异常 辛伐他汀 甘油三酯 总胆固醇 安全性 有效性 

分 类 号：R255.4[医药卫生—中医内科学]