驱动蛋白分子KIF18A的结构与功能研究进展  

Research progresses on the structure and function of KIF18A

作　　者：朱长军[1,2,3] 周之春 ZHU Changjun;ZHOU Zhichun(College of Life Sciences,Tianjin Normal University,Tianjin 300387,China;Key Laboratory of Molecular and Cellular Systems Biology,Tianjin Normal University,Tianjin 300387,China;Tianjin Key Laboratory of Animal and Plant Resistance,Tianjin Normal University,Tianjin 300387,China)

机构地区：[1]天津师范大学生命科学学院,天津300387 [2]天津师范大学分子细胞系统生物学重点实验室,天津300387 [3]天津师范大学天津市动植物抗性重点实验室,天津300387

出　　处：《天津师范大学学报（自然科学版）》2020年第6期1-8,共8页Journal of Tianjin Normal University：Natural Science Edition

基　　金：国家自然科学基金面上资助项目(30971446);天津市科技支撑计划重点资助项目(S18ZC71124);天津市高校“十三五学科领军人才培养计划”资助项目(135205LJ24).

摘　　要：KIF18A是驱动蛋白kinesin-8家族中的一员,在细胞内能够依靠水解ATP释放的能量,以微管为轨道向正极方向运动.同时,KIF18A定位在微管正极末端,可调控微管的动态不稳定性,发挥类似于微管解聚酶的活性.在有丝分裂过程中,KIF18A能够调控纺锤体微管动力学和染色体振幅,对有丝分裂期染色体及时完成整列、维持基因组稳定和顺利完成有丝分裂具有关键作用.本文对KIF18A蛋白的分子结构、胞内定位、细胞周期调控功能及其与肿瘤发生、发展的关系等方面进行了详细阐述.KIF18A,a member of the kinesin-8 family,moves towards the plus-end direction of microtubules powered by the energy derived from ATP hydrolysis in cells.Meanwhile,KIF18A is positioned at the plus-end of the microtubule to regulate the dynamic instability of the microtubule and exert the activity of microtubule depolymerase.During mitosis,KIF18A can regulate spindle microtubule dynamics and chromosome amplitude,and plays a key role in the timely completion of chromosome alignment,genomic stability and successful completion of mitosis.In this paper,the molecular structure of KIF18A protein,intracellular localization,cell cycle regulation and its relationship with tumorigenesis and tumor development will be reviewed in detail.

关 键 词：驱动蛋白 KIF18A 细胞有丝分裂 结构 功能 肿瘤发生 

分 类 号：Q51[生物学—生物化学]