18F-FDG PET/CT显像联合肿瘤标志物检测在宫颈癌诊断中的应用  

Application of 18F-FDG PET/CT Imaging Combined with Tumor Markers Detection in Diagnosis of Cervical Cancer

作　　者：严洁 李晓琳 徐慧[1] YAN Jie;LI Xiao-lin;XU Hui(Department of Gynaecology and Obstetrics,Guangyuan Maternal and Child Health Care Hospital,Guangyuan 628000,Sichuan Province,China)

机构地区：[1]广元市妇幼保健院妇产科,四川广元628000

出　　处：《中国CT和MRI杂志》2021年第1期155-157,共3页Chinese Journal of CT and MRI

基　　金：四川省卫生厅科研课题(150697)。

摘　　要：目的探讨18F-脱氧葡萄糖(18F-FDG)正电子发射断层扫描/X线计算机体层扫描(PET/CT)显像联合肿瘤标志物血清鳞状细胞癌抗原(SCC-Ag)、癌胚抗原(CEA)检测在宫颈癌诊断中的应用价值。方法将我院75例拟诊为宫颈癌的患者均进行18F-FDG PET/CT检查和血清SCC-Ag、CEA检查,并以术后病理结果为标准,分析18F-FDG PET/CT、血清SCC-Ag、CEA单独检测及联合检测对宫颈癌的诊断效能。结果75例患者病理结果显示为宫颈癌者64例。18F-FDG PET/CT单独诊断宫颈癌的灵敏度、特异度和准确度分别为87.50%、90.91%和88.00%;血清SCC-Ag单独诊断宫颈癌的灵敏度、特异度和准确度分别为75.00%、81.82%和76.00%;血清CEA单独诊断宫颈癌的灵敏度、特异度和准确度分别为62.50%、72.73%和64.00%;18F-FDG PET/CT+SCC-Ag+CEA诊断宫颈癌的灵敏度、特异度和准确度分别为98.44%、100%和98.67%。18F-FDG PET/CT+SCC-Ag+CEA对宫颈癌诊断灵敏度、准确度均显著高于18F-FDG PET/CT、血清SCC-Ag、CEA单独检查(P<0.05)。结论18F-FDGPET/CT显像联合血清SCC-Ag、CEA检查对宫颈癌诊断效能较高,对临床宫颈癌筛查具有重要价值。Objective To investigate the application value of 18 F-deoxyglucose(18 F-FDG)positron emission tomography/X-ray computed tomography(PET/CT)imaging combined with tumor markers such as serum squamous cell carcinoma antigen(SCC-Ag)and carcino-embryonic antigen(CEA)detection in the diagnosis of cervical cancer.Methods All the 75 patients with cervical cancer diagnosed in the hospital underwent 18 F-FDG PET/CT,serum SCC-Ag and CEA examinations.Taking the postoperative pathological results as the standard,the diagnostic efficiency for cervical cancer by the combination detection of 18 F-FDG PET/CT,serum SCC-Ag and CEA or the single detection with either of the three was analyzed.Results In the 75 patients,there were 64 cases with cervical cancer showed by the pathological results.The sensitivity,specificity and accuracy for diagnosis of cervical cancer by 18 F-FDG PET/CT were 87.50%,90.91%and 88.00%,respectively.The above indexes by serum SCC-Ag were 75.00%,81.82%and 76.00%,respectively.The above indexes by serum CEA were 62.50%,72.73%and 64.00%,respectively.The above indexes by the combination detection of 18 F-FDG PET/CT,serum SCCAg and CEA were 98.44%,100%and 98.67%,respectively.The sensitivity and accuracy for diagnosis of cervical cancer by the combination detection were significantly higher than those by the single detection with either of the three(P<0.05).Conclusion 18 F-FDG PET/CT imaging combined with serum SCC-Ag and CEA has higher diagnostic efficiency for cervical cancer and is of great value for screening of clinical cervical cancer.

关 键 词：18F-脱氧葡萄糖PET/CT显像 肿瘤标志物 宫颈癌 诊断价值 

分 类 号：R445.6[医药卫生—影像医学与核医学] R446[医药卫生—诊断学]