胃癌CT征象与HER2基因表达的相关性研究  

Relationship Between CT Characteristics and Human Epidermal Growth Factor Receptor 2 Expression in Gastric Cancers

作　　者：郑红伟 彭晓博[1] 郑凌云 随晶 王秀艳 祁佩红 祁良[3] ZHENG Hong-wei;PENG Xiao-bo;ZHENG Ling-yun;SUI Jing;WANG Xiu-yan;QI Pei-hong;QI Liang(Department of Image,Henan Provincial Hospital,Zhengzhou 450019,Henan Province,China;Department of Imaging,Zhengzhou People's Hospital,Zhengzhou 450003,Henan Province,China;Department of Imaging,First Affiliated Hospital of Nanjing Medical University,Zhengzhou 450019,Henan Province,China)

机构地区：[1]河南省省立医院影像科,河南郑州450019 [2]郑州人民医院影像科,河南郑州450003 [3]南京医科大学第一附属医院影像科,江苏南京210029

出　　处：《中国CT和MRI杂志》2021年第1期161-164,共4页Chinese Journal of CT and MRI

摘　　要：目的探讨胃癌患者CT征象与人表皮生长因子受体-2(HER-2)基因表达的相关性。方法收集经病理证实为胃癌的433例患者临床和影像资料,根据HER2基因表达情况将患者分为HER2阴性组和HER2阳性组,比较组间CT影像征象的差异。结果与HER2阴性组相比,HER2阳性组更常出现较低N分期(P<0.001),肿瘤边界模糊(P<0.05)和门静脉期强化明显(P<0.001)。HER2阴性组胃癌患者胃壁增厚程度略高于HER2阳性组,HER2阳性组出现肝转移和腹膜种植转移的发生率稍高于HER2阴性组,但二者差异无统计学意义(P>0.05)。结论与HER2阴性胃癌患者相比,HER2阳性组更常出现肿瘤边界模糊、较低的N分期及门静脉期明显强化。Objective To explore the correlation between CT features and human epidermal growth factor receptor2(HER2)-expression status in patients with pathologically-proven gastric cancers.Methods The clinical and imaging data of 433 patients with gastric cancer confirmed by pathology were collected.According to HER2 gene expression,the patients were divided into HER2 negative group and HER2 positive group.Statistical analyzes were used to compare the differences of CT signs between groups.Results Compared with HER2-negative gastric cancers,HER2-positive gastric cancers showed lower N stages(P<0.001),poor defined margins(P<0.05),and hyper-attenuation on portal phase(P<0.001).HER2-negative cancers were slightly thicker than HER2-positive cancers,hepatic metastases and peritoneal seeding were slightly more frequently found in HER2-positive cancers,but the difference was not statistically significant(P>0.05).Conclusion Compared with HER2 negative gastric cancer patients,HER2 positive patients were more likely to have fuzzy tumor boundary,lower N stage and portal venous phase enhancement.

关 键 词：胃癌 人表皮生长因子受体2 计算机体层成像 

分 类 号：R445[医药卫生—影像医学与核医学] R735[医药卫生—诊断学]