外泌体在休克发展进程中的作用  

Exosomes and its role in the development of shock

作　　者：范泽华 郜思齐 赵自刚[1] 牛春雨 Fan Zehua;Gao Siqi;Zhao Zigang;Niu Chunyu(Institute of Microcirculation,Hebei North University,Zhangjiakou;Hebei Medical University,Shijiazhuang,China)

机构地区：[1]河北北方学院微循环研究所 [2]河北医科大学

出　　处：《实用休克杂志（中英文）》2020年第4期228-231,241,共5页Journal of Practical Shock

基　　金：国家自然科学基金面上项目(项目编号:81770492、30370561)。

摘　　要：外泌体是由多种细胞分泌的双层膜囊泡,广泛存在于体液中并直接参与细胞间信息传递,在不同类型休克引起的多器官功能障碍或衰竭的发生过程中发挥关键作用。本文综述外泌体在不同类型休克发展进程中的作用,阐述正常细胞来源外泌体的心肌与神经保护作用,希望通过外泌体的研究为休克的防治探索新的思路。Exosomes are bilayer vesicles secreted by various cells,and widely exist in body fluid and directly participate in the information transmission between cells,and play a crucial role in multiple organ dysfunction syndrome(MODS)and failure caused by multiple types of shock.This article reviews the role and mechanism of exocrine in various shock processes,represents the cardioprotective and neuroprotective effects of exosomes derived from normal cells,and hopes to find new idea of the prevention and treatment of shock through the exosomes research.

关 键 词：外泌体 休克 多器官功能障碍综合征 

分 类 号：R459.7[医药卫生—急诊医学]