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作 者:陈静 CHEN Jing(Fuxin Diabetes Hospital,Fuxin 123000,China)
出 处:《中国现代药物应用》2020年第22期95-97,共3页Chinese Journal of Modern Drug Application
摘 要:目的观察依那普利联合乐卡地平治疗高血压早期肾损害的临床疗效。方法100例高血压早期肾损害患者,采用随机数字表法分为参照组和观察组,各50例。参照组患者采用依那普利治疗,观察组患者采用依那普利联合乐卡地平治疗。对比两组患者治疗后的肾功能指标和血压情况。结果治疗后,观察组患者微量清蛋白(MA)(14.97±6.81)mg/L、血尿素氮(BUN)(4.28±0.52)mmol/L、血肌酐(Scr)(74.61±9.08)μmol/L及舒张压(DBP)(82.56±6.98)mm Hg(1 mm Hg=0.133 kPa)、收缩压(SBP)(132.78±7.41)mm Hg均低于参照组的(18.66±7.54)mg/L、(5.73±0.75)mmol/L、(82.03±9.67)μmol/L、(89.03±7.42)mm Hg、(145.73±6.79)mm Hg,差异有统计学意义(P<0.05)。结论针对高血压早期肾损害患者采用依那普利联合乐卡地平治疗,其不仅可以进一步改善肾功能指标,同时还可以在更大程度上稳定血压,建议积极推广。Objective To observe the clinical efficacy of enalapril combined with lercanidipine in the treatment of patients with early renal damage due to hypertension.Methods A totla of 100 patients with early renal damage due to hypertension were divided into reference group and observation group according to random numerical table,with 50 cases in each group.The reference group was treated with enalapril,and the observation group was treated with enalapril combined with lercanidipine.The renal fucntion indexes and blood pressure after treatment were compared between the two groups.Results After treatment,microalbumin(MA)(14.97±6.81)mg/L,blood urea nitrogen(BUN)(4.28±0.52)mmol/L,blood creatinine(Scr)(74.61±9.08)μmol/L and diastolic blood pressure(DBP)(82.56±6.98)mm Hg(1mm Hg=0.133 kPa)and systolic blood pressure(SBP)(132.78±7.41)mm Hg of the observation group were lower than(18.66±7.54)mg/L,(5.73±0.75)mmol/L,(82.03±9.67)μmol/L,(89.03±7.42)mm Hg,(145.73±6.79)mm Hg of the reference group,and the difference was statistically significant(P<0.05).Conclusion Enalapril combined with lercanidipine can not only further improve renal function index,but also stabilize blood pressure to a greater extent in patients with early renal damage due to hypertension.
关 键 词:高血压 早期肾损害 依那普利 乐卡地平 肾功能 血压水平
分 类 号:R544.1[医药卫生—心血管疾病] R692[医药卫生—内科学]
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