环磷酰胺冲击联合激素治疗难治性肾病综合征的疗效观察  

Effect of cyclophosphamide pulse combined with hormone on refractory nephrotic syndrome

作　　者：李姝 郭伟[1] LI Shu(Department Two of Nephrology,Shenyang Forth People’s Hospital,Shenyang 110031,China)

机构地区：[1]沈阳市第四人民医院肾内二科,110031

出　　处：《中国现代药物应用》2020年第22期105-107,共3页Chinese Journal of Modern Drug Application

摘　　要：目的观察分析环磷酰胺冲击联合激素治疗难治性肾病综合征的疗效。方法60例难治性肾病综合征患者,依据治疗方法不同分成对照组和观察组,每组30例。对照组患者采用常规激素进行治疗,观察组患者利用环磷酰胺冲击联合激素进行治疗。对比两组患者的临床疗效以及不良反应发生情况。结果观察组患者治疗总缓解率96.67%高于对照组的73.33%,差异有统计学意义(P<0.05)。观察组患者的不良反应发生率6.67%低于对照组的26.67%,差异有统计学意义(P<0.05)。结论在对难治性肾病综合征进行治疗时,利用环磷酰胺冲击联合激素治疗的方式,治疗效果显著,不良反应发生率较低,值得在临床中进行推广。Objective To observe and analyze the efficacy of cyclophosphamide pulse combined with hormone on refractory nephrotic syndrome.Methods A total of 60 patients with refractory nephrotic syndrome were divided into control group and observation group according to different treatment methods,with 30 cases in each group.The control group was treated with conventional hormone therapy,and the observation group was treated with cyclophosphamide pulse combined with hormone.The clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results The total remission effective rate 96.67%of the observation group was higher than 73.33%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 6.67%of the observation group was lower than 26.67%of the control group,and the difference was statistically significant(P<0.05).Conclusion Cyclophosphamide pulse combined with hormone shows remarkable effect on refractory nephrotic syndrome with low incidence of adverse reactions,which is worthy of clinical promotion.

关 键 词：难治性肾病综合征 环磷酰胺 冲击治疗 激素 

分 类 号：R692[医药卫生—泌尿科学]