雄激素源性脱发的动物模型研究进展  

Research progress on animal models of androgenic alopecia

作　　者：黄丹[1] 冷静 殷国前[1] 严玉勇 林博杰[1] Huang Dan;Leng Jing;Yin Guoqian;Yan Yuyong;Lin Bojie(Department of Plastic Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;School of Basic Medicine,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西医科大学第一附属医院整形美容外科,南宁530021 [2]广西中医药大学基础医学院,南宁530200

出　　处：《中华实验外科杂志》2020年第11期2163-2167,共5页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金青年科学基金项目(81701938);广西科技重大专项(桂科AA17292008);广西自然科学基金青年科学基金项目(2018GXNSFBA050025、2020GXNSFAA999005);中国博士后科学基金面上项目(2019M663410)。

摘　　要：雄激素源性脱发,是最常见的脱发类型。临床上脱发虽然不会带来身体上的损害,但是严重影响患者心理。随着社会经济发展,人们对美容外观需求逐渐提高,针对脱发的研究也越发受到学界重视。雄激素源性脱发的动物模型在探究其发病机制和筛选治疗方法中发挥着关键作用。本文根据文献报道回顾了雄激素源性脱发动物模型的相关研究,对脱发病因、造模类型及造模效果等方面进行简单综述,并对动物模型在临床中的转化应用进行总结和展望。Androgenic alopecia is the most common type of hair loss.Although clinical hair loss will not cause physical damage,but seriously affect the patient’s psychology.With the social and economic development,people’s demand for appearance is gradually increasing,and the research on hair loss has also been paid more and more attention by academia.Animal models of androgenic alopecia play a key role in exploring its pathogenesis and screening treatment methods.This paper reviews the relevant studies of animal models of androgenetic alopecia based on literature reports,briefly reviews the etiology of alopecia,types of modeling,and effects of modeling,and summarizes and prospects the application of animal models in clinical transformation.

关 键 词：雄激素源性脱发 模型 动物 研究进展 

分 类 号：R758.71[医药卫生—皮肤病学与性病学] R-332[医药卫生—临床医学]