小青龙汤加减联合布地奈德福莫特罗吸入剂对哮喘急性发作患者肺功能及血清TGF-β1、IL-8水平的影响  

Effect of Xiaoqinglong Decoction Combined with Budesonide Formoterol Inhaler on Lung Function and Serum TGF-β1 and IL-8 Levels in Patients with Acute Asthma Attack

作　　者：赵栋梁[1] ZHAO Dongliang(Department of Pulmonary Disease,the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Henan Province,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第三附属医院肺病科,河南郑州450000

出　　处：《光明中医》2020年第21期3439-3441,共3页GUANGMING JOURNAL OF CHINESE MEDICINE

摘　　要：目的研究小青龙汤加减联合布地奈德福莫特罗吸入剂对哮喘急性发作患者的肺功能及血清TGF-β1、IL-8水平的影响。方法选取收治的130例哮喘急性发作患者作为研究对象,以随机数字表法分为2组,每组65例。对照组使用布地奈德福莫特罗吸入剂治疗,观察组则联合小青龙汤加减治疗,治疗周期均为4周。比较2组患者临床疗效,治疗前后肺功能指标及血清TGF-β1、IL-8水平变化。结果观察组患者临床总有效率为92.31%,高于对照组的73.85%。与治疗前相比,治疗后2组患者FEV1、PEF、FEV1/FVC均升高,且观察组高于对照组;血清IL-8、TGF-β1水平均降低,且观察组低于对照组(均P<0.05)。结论小青龙汤加减联合布地奈德福莫特罗吸入剂可有效缓解哮喘急性发作患者的临床症状,改善肺功能,降低炎症反应,值得临床进一步推广应用。Objective To investigate the effects of Xiaoqinglong decoction combined with budesonde formoterol inhaler on lung function and serum TGF-β1 and IL-8 levels in patients with acute asthma. Methods A total of 130 patients with acute attacks of asthma admitted to our hospital were selected as the research objects. They were divided into two groups by random number table method,with 65 patients in each group. The control group was treated with budesonid formoterol inhaler,while the observation group was treated with Xiaoqinglong decoction combined with budesonde formoterol inhaler for 4 weeks. The clinical efficacy,pulmonary function indexes and serum TGF-β1 and IL-8 levels before and after treatment were compared between the two groups. Results The total effective rate was 92. 31% in the experimental group,which was higher than 73. 85% in the control group. Compared with before treatment,FEV1,PEF and FEV1/FVC were increased in both groups after treatment,and the observation group was higher than the control group. Serum levels of IL-8 and TGF-β1 all decreased,and those in the observation group were lower than those in the control group( all P < 0. 05). Conclusion Xiaoqinglong decoction combined with budesonde formoterol inhaler can effectively relieve the clinical symptoms,improve lung function and reduce inflammation in patients with acute asthma attack,which is worthy of further clinical application.

关 键 词：小青龙汤 布地奈德福莫特罗吸入剂 哮喘 转化生长因子-β1 白介素-8 中西医结合疗法 

分 类 号：R562.25[医药卫生—呼吸系统]