基质金属蛋白酶⁃9及金属蛋白酶组织抑制剂1在呼吸道合胞病毒毛细支气管炎进展为哮喘中的意义  

Significance of matrix metalloproteinase⁃9 and matrix metalloproteinase tissue inhibitor 1 in progression of respiratory syncytial virus bronchiolitis to asthma

作　　者：康平 孙晓敏[2] 赵少聪 冯一川 李奕 KANG Ping;SUN Xiaomin;ZHAO Shaocong;FENG Yichuan;LI Yi(Respiratory Department,Children′s Hospital Affiliated of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学附属儿童医院呼吸科,郑州450000 [2]郑州大学附属儿童医院普内科,郑州450000 [3]郑州大学附属儿童医院检验科,郑州450000 [4]郑州大学附属儿童医院过敏原治疗室,郑州450000

出　　处：《实用医学杂志》2020年第22期3135-3139,共5页The Journal of Practical Medicine

基　　金：2018河南省医学科技攻关计划(联合共建项目)(编号:2018020681)。

摘　　要：目的探讨血清基质金属蛋白酶⁃9(MMP⁃9)及金属蛋白酶组织抑制剂1(TIMP⁃1)在呼吸道合胞病毒(RSV)毛细支气管炎中的意义。方法检测毛细支气管炎患儿(RSV组)及健康对照组血清MMP⁃9和TIMP⁃1的含量,根据随访结果将RSV组分为非哮喘组和哮喘组。ROC曲线及logistic回归分析MMP⁃9、TIMP⁃1和MMP⁃9/TIMP⁃1在RSV毛细支气管炎及其进展为哮喘中的诊断性能。结果RSV组MMP⁃9、TIMP⁃1和MMP⁃9/TIMP⁃1水平均显著高于对照组(P<0.05),其诊断RSV毛细支气管炎的AUC分别为0.942、0.579、0.827。哮喘组MMP⁃9及MMP⁃9/TIMP⁃1显著高于非哮喘组(P<0.05);MMP9、MMP⁃9/TIMP⁃1是RSV毛细支气管炎向哮喘进展的独立危险因素(P<0.05)。结论血清MMP⁃9、TIMP⁃1水平对RSV毛细支气管炎病情进展具有一定提示意义。Objective To investigate the significance of serum matrix metalloproteinase⁃9(MMP⁃9)and matrix metalloproteinase tissue inhibitor 1(TIMP⁃1)in the development of respiratory syncytial virus(RSV)bronchiolitis to asthma.Methods The serum MMP⁃9 and TIMP⁃1 of RSV bronchiolitis children(RSV group)and health control were determined,and the RSV group were divided into non⁃asthmatic subgroup and asthma subgroup according to the follow⁃up results.ROC curve and logistic regression were used to analyze the performance of MMP⁃9,TIMP⁃1 and MMP9/TIMP⁃1 in the diagnosis of RSV bronchiolitis and its progression to asthma.Results Compared with those in the control group,MMP⁃9,TIMP⁃1 and MMP9/TIMP⁃1 in the RSV group were significantly increased(P<0.05).The area under the curve(AUC)of MMP⁃9,TIMP⁃1 and MMP9/TIMP⁃1 for the diagnosis of RSV bronchiolitis was 0.942,0.579,and 0.827,respectively.Compared with those in non⁃asthmatic group,MMP⁃9 and MMP9/TIMP⁃1 in asthma group were significantly increased(P<0.05).MMP⁃9 and MMP⁃9/TIMP⁃1 were independent risk factors in the development of RSV bronchiolitis to asthma(P<0.05).Conclusion Serum MMP⁃9 and TIMP⁃1 have certain significance in RSV bronchiolitis and its progression to asthma.

关 键 词：呼吸道合胞病毒 毛细支气管炎 哮喘 基质金属蛋白酶⁃9 基质金属蛋白酶组织抑制剂1 

分 类 号：R725.6[医药卫生—儿科]