胸腔积液结核分枝杆菌感染T细胞检测对结核性胸膜炎的诊断价值研究  

Value of T-SPOT.TB assay from pleural fIuid in diagnosis of tuberculous pleurisy

作　　者：方圆 赵峰 陈佩 吴朔 陈丽展 FANG Yuan;ZHAO Feng;CHEN Pei(Department of Respiratory Medicine,Xijing Hospital,Air Force Medical University,Xi’an 710032)

机构地区：[1]空军军医大学西京医院呼吸内科,西安710032 [2]西安国际医学中心医院胸科医院呼吸内科,西安710100

出　　处：《陕西医学杂志》2020年第12期1681-1683,1687,共4页Shaanxi Medical Journal

基　　金：国家科技重大专项课题(2017ZX10103004)。

摘　　要：目的:探讨胸腔积液结核分枝杆菌感染T细胞检测(T-SPOT.TB)对结核性胸膜炎的诊断价值。方法:选择75例胸腔积液患者为研究对象,其中结核性胸膜炎患者52例(结核组),非结核性胸膜炎患者23例(非结核组)。比较两组患者胸腔积液T-SPOT.TB、腺苷脱氨酶(ADA)及外周血T-SPOT.TB水平。通过受试者工作特征(ROC)曲线分析胸腔积液T-SPOT.TB、ADA及外周血T-SPOT.TB对结核性胸膜炎的诊断效能。结果:两组患者胸腔积液T-SPOT.TB、ADA及外周血T-SPOT.TB比较,差异均具有统计学意义(P<0.05)。在诊断结核性胸膜炎方面,胸腔积液T-SPOT.TB表现出较高的敏感度及特异度。结论:与其他检测指标相比,胸腔积液T-SPOT.TB的灵敏度和特异度较高,可以提高诊断的准确率。Objective:To evalutate the value of T-SPOT.TB from pleural fIuid in the diagnosis of tuberculous pleurisy(TBP).Methods:75 patients with pleural effusion were selected as the research objects,including 52 patients with tuberculous pleurisy(tuberculosis group)and 23 patients with non tuberculous pleurisy(non tuberculosis group).The levels of T-SPOT.TB and ADA in pleural effusion and T-SPOT.TB in peripheral blood were compared between the two groups.The receiver operating characteristic(ROC)curve was used to analyze the diagnosic value of indicators above mentioned.Results:There were significant differences in T-SPOT.TB and ADA in pleural effusion and T-SPOT.TB in peripheral blood between the two groups(P<0.05).In the diagnosis of tuberculous pleurisy,T-SPOT.TB assay from pleural effusion showed higher sensitivity and specificity.Conclusion:Compared with other detection indexes,the sensitivity and specificity of T-SPOT.TB from pleural fIuid are better,which can improve diagnostic accuracy.

关 键 词：结核性胸膜炎 结核分枝杆菌感染T细胞检测 腺苷脱氨酶 胸腔积液 诊断效能 

分 类 号：R529.3[医药卫生—内科学]