超声造影定量分析技术对肝血管瘤的诊断价值  

Diagnostic value of contrast-enhanced ultrasonography in hepatic hemangioma

作　　者：丁钱山 吴意赟[1] 马云飞[1] 沈碧潇 蔡婷[1] 毛书霞 DING Qianshan;WU Yiyun;MA Yunfei;SHENG Bixiao;CAI Ting;MAO Shuxia(The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029

出　　处：《现代医学》2020年第9期1173-1176,共4页Modern Medical Journal

基　　金：江苏省第五期“333高层次人才培养工程”项目(LGY2018063);江苏省“六大人才高峰”第十二批项目(WSN-053)。

摘　　要：目的:探讨超声造影定量分析技术对肝血管瘤的诊断价值。方法:选取2015年4月至2019年2月江苏省中医院收治的肝血管瘤患者60例。其中51例经增强CT及增强磁共振成像证实、9例经手术病理证实,均为海绵状血管瘤。利用分析软件对肝血管瘤及周围正常肝组织进行定量分析,获取以下参数:上升时间(RT)、峰值强度(PI)、平均渡越时间(MTT)、曲线下面积(AUC)、峰值降半时间(TPH)、上升斜率(WIS)、达峰时间(TTP)。采用t检验分别比较肝血管瘤与周围正常肝组织各参数差异,并用受试者工作特征曲线(ROC曲线)比较各参数在诊断肝血管瘤中的价值。结果:肝脏血管瘤的RT、MTT和TTP均小于周围正常肝组织(t值分别为-3.746、-2.194、-4.513,P<0.05);TPH高于周围正常肝组织(t=2.019,P<0.05);PI、AUC和WIS均高于周围正常肝组织(t=8.063、7.209、6.560,P均<0.05)。ROC曲线显示WIS较其他参数诊断准确性高,敏感性为86.7%,特异性为66.7%。结论:超声造影定量分析技术较二维超声及常规超声造影能够更客观、准确地评估肝脏血管瘤特征,有助于肝脏血管瘤的诊断,其中WIS与其他参数相比诊断准确性更高。Objective:To evaluate the diagnostic value of contrast-enhanced ultrasonography(CEUS)in hepatic hemangioma.Methods:Totally 60 cases of patients with hemangioma were selected from April 2015 to February 2019 in the Affiliated Hospital of Nanjing University of Chinese Medicine,of whom 51 cases were confirmed by CT and magnetic resonance imaging(MRI),and 9 cases were proved by surgery pathology to be cavernous hemangioma.Quantitative analysis of hepatic hemangioma and surrounding normal liver parenchyma was carried out with analysis software to obtain the following CEUS quantitative parameters,i.e.,the rise time(RT),the peak intensity(PI),the mean transit time(MTT),the area under the curve(AUC),the time from peak to half(TPH),the wash in slope(WIS)and the time to peak(TTP).T-test was used to compare the differences of parameters between hepatic hemangioma and surrounding normal liver tissue,and the value of each parameter in the diagnosis of hepatic hemangioma was compared with the subject operating characteristic(ROC)curve.Results:RT,MTT and TTP in hemangioma were shorter than those in normal liver parenchyma,TPH was longer in hemangioma,and PI,AUC and WIS were higher in hemangioma,the differences being statistically significant.ROC curve showed that WIS was more accurate than other parameter with a sensitivity of 86.7%and a specificity of 66.7%.Conclusion:Contrast-enhanced ultrasound quantitative analysis technology can more objectively and accurately evaluate the characteristics of hepatic hemangioma,which is helpful to the diagnosis of hepatic hemangioma,and the accuracy of WIS is higher than that of other parameters.

关 键 词：超声造影 肝脏 肝血管瘤 

分 类 号：R445.1[医药卫生—影像医学与核医学] R735.7[医药卫生—诊断学]