拮抗剂方案助孕hCG日雌二醇水平对妊娠结局的影响  

Effect of estradiol level on pregnancy outcome on the hCG day of antagonist protocol

作　　者：王葳 曹义娟[1,2] 马娟 WANG Wei;CAO Yi-juan;MA Juan(Xuzhou Clinical College of Xuzhou Medical University,Xuzhou Jiangsu 221000;Clinical Center of Reproductive Medicine,Xuzhou Central Hospital,Xuzhou Jiangsu 221000;Department of Reproductive Medicine,The General Hospital of Wanbei Coal-electricity Group,Suzhou Anhui 234000,China)

机构地区：[1]徐州医科大学徐州市临床学院,江苏徐州221000 [2]江苏省徐州市中心医院生殖中心,221000 [3]皖北煤电集团总医院生殖医学科,安徽宿州234000

出　　处：《蚌埠医学院学报》2020年第11期1494-1497,共4页Journal of Bengbu Medical College

基　　金：江苏省徐州市科技计划项目(KC17104)。

摘　　要：目的:探讨拮抗剂方案人绒毛膜促性腺激素(hCG)日血清雌二醇(E2)水平对新鲜胚胎移植周期妊娠结局的影响。方法:回顾性分析行体外受精-胚胎移植/卵胞浆内单精子注射(IVF/ICSI)拮抗剂方案助孕共216个周期病人的临床资料。根据hCG日E2水平将其分为4组:A组<1600 pg/mL,B组1600~3200 pg/mL,C组>3200~4800 pg/mL,D组>4800 pg/mL。比较各组获卵数、单个卵泡E2水平、获胚胎数、受精率、卵裂率、优质胚胎率、胚胎种植率、临床妊娠率和早期流产率。结果:B、C、D组获卵数、获胚胎数较A组高,C、D组较B组高,D组较C组高(P<0.05)。C、D组单个卵泡E2水平较A组高,D组较B组高(P<0.05)。D组胚胎种植率较B、C组低(P<0.05),4组受精率、卵裂率、优质胚胎率、临床妊娠率及早期流产率差异均无统计学意义(P>0.05)。结论:拮抗剂方案中高E2水平病人获卵数及获胚胎数增多,优质胚胎率不会受到影响,但鲜胚移植胚胎种植率降低。Objective:To investigate the effect of estradiol(E2)level on the human chorionic gonadotropin(hCG)day of antagonist protocol on the pregnancy outcome of fresh embryo transfer cycle.Methods:The clinical data of 216 cycles of in vitro fertilization and embryo transfer/intra cytoplasmic sperm injection(IVF/ICSI)antagonist protocol were retrospectively analyzed.According to the E2 level on hCG day,the patients were divided into group A(<1600 pg/mL),group B(1600-3200 pg/mL),group C(>3200-4800 pg/mL),and group D(>4800 pg/mL).The number of obtained oocytes,E2 level of single follicle,number of obtained embryos,fertilization rate,cleavage rate,high-quality embryo rate,embryo implantation rate,clinical pregnancy rate and early abortion rate were compared between the two groups.Results:The number of obtained oocytes and obtained embryos in group B,group C and group D was higher than that in group A,which in group C and group D was higher than that in group B,and which in group D was higher than that in group C(P<0.05).The E2 level of single follicle in group C and group D was higher than that in group A,which in group D was higher than that in group B(P<0.05).The embryo implantation rate in group D was lower than that in group B and group C(P<0.05).There was no statistical difference in fertilization rate,cleavage rate,high-quality embryo rate,clinical pregnancy rate and early abortion rate among the four groups(P>0.05).Conclusions:In the antagonist protocol,the number of obtained oocytes and embryos in patients with high E2 level increases,and the rate of high-quality embryos is not affected,but the implantation rate of fresh embryo transfer decreases.

关 键 词：人绒毛膜促性腺激素 雌二醇 拮抗剂方案 妊娠 

分 类 号：R714.8[医药卫生—妇产科学]