干扰素雾化治疗小儿急性毛细支气管肺炎的疗效与安全性分析  

Efficacy and Safety Analysis of Interferon Atomization in the Treatment of Acute Bronchiolitis Pneumonia in Children

作　　者：吴晓蕾 Wu Xiaolei(Nanle County People's Hospital,Puyang,Henan Province,Puyang 457400)

机构地区：[1]河南省濮阳市南乐县人民医院,濮阳457400

出　　处：《数理医药学杂志》2020年第12期1823-1825,共3页Journal of Mathematical Medicine

摘　　要：目的:探讨小儿急性毛细支气管肺炎实施干扰素雾化治疗的疗效与安全性。方法:将儿科80例小儿急性毛细支气管肺炎患儿(2017年7月~2019年2月)用计算机实施随机分组,分为一般组(一般对症治疗)和干扰素组(干扰素雾化吸入辅助治疗)各40例,对比两组疗效、康复进程、血清炎症指标、T细胞亚群及用药不良反应。结果:干扰素组治疗后总有效率、白细胞介素-10、CD4+、CD4+/CD8+与一般组组间对比更高,干扰素组治疗后喘憋、咳嗽、哮鸣音、三凹症消失时间及白细胞介素-4与一般组组间对比更低(P<0.05);干扰组不良反应总发生率与一般组相比无明显差异(P>0.05)。结论:小儿急性毛细支气管肺炎实施干扰素雾化治疗的疗效及安全性高。Objective:To investigate the efficacy and safety of interferon atomization in children with acute bronchiolitis pneumonia.Methods:80 children with acute bronchiolitis pneumonia(July 2017 to February 2019)were selected and divided into general group(n=40,general and symptomatic treatment)and interferon group(n=40,interferon atomization inhalation therapy),then the curative effect,healing process,serum inflammation index,T cell subsets,and drug adverse reactions were summarized.Results:Compared with the general group,the total effective rate,interleukin-10,CD4+,CD4+/CD8+were higher in the interferon group.The time of disappearance of asthma,cough,wheezing and three concave symptoms and interleukin-4 in interferon group after treatment were lower than those in general group(P<0.05).Conclusion:Interferon atomization is effective and safe in children with acute bronchiolitis pneumonia.

关 键 词：小儿急性毛细支气管肺炎 干扰素 雾化 安全性 

分 类 号：R725.6[医药卫生—儿科]