质子引起天然铀裂变产生医用同位素钼-99的研究  

The Study on Molybdenum-99 Via Proton-Induced the Fission of Natural Uranium

作　　者：王洁茹[1,2,3] 陈德胜 黄清钢 秦芝 郭治军[2] 吴晓蕾 初剑[1,3] 白静[1] 田伟 范芳丽[1] 殷小杰[1] 谈存敏[1] 曹石巍[1] WANG Jieru;CHEN Dengsheng;HUANG Qinggang;QIN Zhi;GUO Zhijun;WU Xiaolei;CHU Jian;BAI jing;TIAN Wei;FAN fangli;YIN Xiaojie;TAN Cunmin;CAO Shiwei(Institute of Mordern Physics,Chinese Academy of Sciences;School of Nuclear Science and Technology,Lanzhou University;School of Nuclear Science and Technology,University of Chinese Academy of Sciences)

机构地区：[1]中国科学院近代物理研究所,兰州730000 [2]兰州大学核科学与技术学院,兰州730000 [3]中国科学院大学核科学与技术学院,北京100000

出　　处：《同位素》2020年第6期347-355,共9页Journal of Isotopes

基　　金：兰州大学中央高校基本科研业务费专项资金项目(lzujbky-2020-kb11);国家自然科学基金项目(12005272);国家自然科学基金项目(11905266);甘肃省引导科技创新发展专项资金项目(项目名称:基于强流超导直线加速器的医用同位素研发);中国科学院西部之光青年学者项目(29Y812010)。

摘　　要：医用同位素锝-99m(99mTc)被广泛应用于核医学领域,其主要来源于母体核素钼-99(99Mo)的衰变。但是目前国内99Mo基本依赖进口,通常出现99Mo不能稳定供应的现象。为解决这个重大问题,实现国内99Mo自主化生产具有重要意义。本文基于中国科学院近代物理研究所强流超导直线加速器(China ADS Front End,CAFE)提供的质子束流辐照天然铀靶件,主要开展铀裂变产物中医用同位素99Mo的高效化学分离、纯化及99Mo/99mTc发生器的制备。研究表明:通过α-安息香肟(α-BO)沉淀分离99Mo后,杂质核素去除率大于90%,99Mo的回收率大于90%。通过对99Mo沉淀进行纯化后,大部分杂质核素被去除。提取的99Mo被装配为99Mo/99mTc发生器,发生器淋洗曲线表明:99mTc产品收集在8 mL生理盐水内最为适宜,同时,99mTc回收率大于80%。电感耦合等离子体发射光谱仪(ICP-OES)测量结果表明,99mTc产品中Al、Mo以及U含量极低;同时,99mTc产品的γ谱图中未出现99Mo和其他杂质核素的γ能量峰。以上研究结果可为国内基于加速器辐照天然铀生产99Mo提供技术参考。The radionuclide Technetium-99 m(99 mTc)has been widely used in nuclear medicine.It is known that 99 mTc is mainly obtained from the decay of molybdenum-99(99Mo).Most of 99Mo used in China is imported from foreign country,causing an issue about the unstable supply of 99Mo.In order to solve the major problem,realizing the domestic production of 99Mo is of great significance in China.In this paper,based on China ADS Front End(CAFE)of Institute of Morden Physic(IMP),the natUO2 target irradiation,the 99Mo separation with high-efficiency,the purification of 99Mo and the preparation of 99Mo/99 mTc generator were investigated systematically.The results of 99Mo precipitation byα-benzoinoxime(α-BO)indicated that the removal ratio of other nuclides can reach more than 90%and the recovery of 99Mo is also up to 90%.The results on purification of 99Mo revealed that the most nuclides were nearly removed.The 99Mo/99 mTc generator has been prepared with extracted 99Mo adsorbed on acid-treated alumina in a lead shield.The elution profile of 99 mTc from 99Mo/99 mTc generator with saline showed that 99 mTc can be eluted in the 8 mL containing of 99 mTc>80%.Inductively Coupled Plasma Optical Emission Spectrometer(ICP-OES)analysis demonstrated that the content of Al,U,Mo is extremely low.The peaks of 99Mo and other nuclides were not be observed in the gamma spectra of the 99 mTc eluent.The above results could provide useful information for the production of 99Mo based on the accelerator in China.

关 键 词：强流超导直线加速器 天然铀 钼-99 分离工艺路线 99Mo/99mTc发生器 

分 类 号：TL922[核科学技术—核燃料循环与材料]