Does endurance training improve red blood cell aging and hemorheology in moderate-trained healthy individuals?  

作　　者：Daniel A.Bizjak Fabian Tomschi Gunnar Bales Elie Nader Marc Romana Philippe Connes Wilhelm Bloch Marijke Grau 

机构地区：[1]Department of Molecular and Cellular Sports Medicine,German Sport University Cologne,Cologne 50933,Germany [2]Laboratoire LIBM EA7424-Equipe“Biologie Vasculaire et du Globule Rouge”,UniversitéClaude Bernard Lyon 1,Villeurbanne 69100,France [3]Laboratoire d’Excellence du Globule Rouge GR-Ex,Paris 75015,France [4]Universitédes Antilles,Inserm,UnitéBiologie Intégrée du Globule Rouge,CHU de PointeàPitre,Pointe_a Pitre,Guadeloupe 97157,France [5]Institut Universitaire de France,Paris 75231,France [6]The German Research Centre of Elite Sport,German Sport University Cologne,Cologne 50933,Germany

出　　处：《Journal of Sport and Health Science》2020年第6期595-603,共9页运动与健康科学（英文）

基　　金：supported by the Hochschulinterne Forschungsforderung(HIF)of the German Sport University Cologne.

摘　　要：Objective:To examine the impact of a 6-week endurance training on red blood cell(RBC)aging and deformability of healthy participants to detect possible improved hemorheological and performance-related adaptations.Methods:A total of 31 participants(17 females and 14 males)performed a 6-week moderate training protocol(three 1-h running sessions per week at 70%of maximal heart rate).Blood was sampled before and after the training.RBCs from each participant were fractioned according to density and age into 4 RBC subfractions.Subfractions were examined for changes of RBC properties,including aging distribution,RBC deformability,RBC microparticles,and phosphatidylserine concentrations.RBC and plasma nitrite levels were measured as indicators of nitric oxide metabolism.Results:Aerobic performance,peak oxygen consumption,ventilatory thresholds,velocity at the aerobic-anaerobic threshold,and lactate at exhaustion improved after training.The relative amount of both young RBCs and old RBCs increased,and the amount of the main RBC fraction decreased.Phosphatidylserine externalization and RBC-derived microparticles decreased.Overall deformability expressed as shear stress required to achieve half-maximum deformation to theoretical maximal elongation index at infinite shear stress improved in unfractioned RBCs(p<0.001).Nitrite decreased in total(p=0.001),young(p<0.001),main(p<0.001),and old(p=0.020)aged RBCs and in plasma(p=0.002),but not in very old RBCs.Conclusion:These results indicate that non-endurance-trained healthy participants benefit from a regular moderate running training program because performance-related parameters improve and a younger RBC population with improved RBC properties is induced,which might support oxygen supply in the microcirculation.

关 键 词：Cellular adaptation HEMORHEOLOGY Nitric oxide Performance RBC physiology and aging 

分 类 号：G804.2[文化科学—运动人体科学]